discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

BACKGROUND Hepatic cirrhosis is a common pathway of progressive liver destruction from multiple causes. Iron uptake can occur within the hepatic parenchyma or within the various nodules that form in a cirrhotic liver, termed siderotic nodules. Siderotic nodule formation has been shown to correlate with inflammatory activity, and while the relationship between siderotic nodule formation and mali...

unitermos abstract The detection of hepatic nodules by imaging techniques in cirrhotic patients has increased and the growing consensus that these lesions may be premalignant increases their clinical importance and demands precise diagnostic criteria. The prevalence of macroscopic suspect hepatic nodule (MSHN) in cirrhotic livers was analyzed to identify macroregenerative nodule (MRN), dysplast...

We report a 72-year-old man who was admitted to our department with multiple nodules of hepatocellular carcinoma (HCC) in a cirrhotic liver because of HCV infection. Unlike most of the nodules, one in segment 2 (S2) showed hypoattenuation on computed tomography (CT) during hepatic arteriography (CTA), and hyperattenuation on CT during arterial portography (CTAP). Fine needle aspiration biopsy o...

Hepatocellular carcinoma (HCC) frequently occurs in association with liver cirrhosis, as chronic liver disease is one of the most important factors in carcinogenesis. In addition to HCCs, recent reports of pathologic studies of resected specimens from cirrhotic liver describe associated small nodular lesions such as regenerative nodule, dysplastic nodule (adenomatous hyperplasia), and dysplasti...

Medullary thyroid carcinoma (MTC) is a rare cause of chronic diarrhea. When systemic symptoms such as diarrhea occur, distal metastasis often exists. The most common clinical presentation of MTC is solitary thyroid nodule. It was uncommon that chronic diarrhea as initial presentation of MTC without visible thyroid nodule. A 66-year-old woman suffered from watery diarrhea for 4 months. Irritable...

In patients with liver cirrhosis, arterial phase enhancement of nodular lesions on helical-CT is currently considered to be highly predictive of malignancy. We report the spontaneous regression of a hypervascular hepatic nodule in a patient with liver cirrhosis within 7 months demonstrated by helical-CT follow-up. This suggests that tumour angiogenesis known to be an obligatory step for acquisi...

S tepwise carcinogenesis of hepatocellular carcinoma (HCC) in the cirrhotic liver has been well described pathologically and radiologically. It is accompanied by sequential hemodynamic changes in the nodules. The dysplastic nodule (DN, adenomatous hyperplasia) and early HCC frequently include portal tract structures without arterial neovascularization. In contrast, advanced HCC is characterized...

Hepatocellular carcinoma may develop from multistep carcinogenesis via dysplastic nodules in the cirrhotic liver. The first stage between high-grade dysplastic nodule to overt hepatocellular carcinoma is vaguely nodular, early hepatocellular carcinoma. The consensus on the nomenclature and pathologic characteristics of both entities were recently established by an international consensus group ...

BACKGROUND During the progression from low-grade dysplastic nodule (DN) to progressed hepatocellular carcinoma (HCC), intranodular portal tracts gradually disappear, while unpaired arteries develop increasingly. Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting intranodular vascularity. This study evaluates the usefulness of CEUS in the characterization of DN, early HCC and pr...