muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. one explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. in mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respirat...

UNLABELLED Hypertrophic cranial pachymeningitis (HCP) is an uncommon disorder characterized by localized or diffuse thickening of the dura mater, and it usually presents with multiple cranial neurophaties. It has been associated with a variety of inflammatory, infectious, traumatic, toxic and neoplasic diseases, when no specific cause is found the process is called idiopathic. The infectious ca...

This report describes heart disease in a 32-year-old man with the syndrome of chronic progressive external ophthalmoplegia (CPEO). The surface electrocardiogram showed first degree AV block and left bundle-branch block and there was HV prolongation on the His bundle electrogram. Endomyocardial biopsy showed the changes of hypertrophy on light microscopy, and on electron microscopy there were in...

Chronic progressive external ophthalmoplegia is one of mitochondrial disorders, characterized by ptosis, limitation of eye movement, variably severe bulbar muscle weakness and proximal limb weakness. Chronic progressive external ophthalmoplegia complicated with acquired disease is extremely rare. We report a 44 years old male patient with more than 20 years of chronic progressive bilateral ptos...

Introduction Mitochondrial diseases are a diverse group with multisystem involvement caused by structural, biochemical or genetic derangement of mitochondria. Cerebral neurones and myocytes which require a high yield of energy are particularly vulnerable to mitochondrial dysfunction and neuromuscular manifestations are common in mitochodrial disorders. We report two cases of mitochondrial myopa...

Dear Editor, We would like to share the results of an anecdotal pilot trial on qigong therapy for chronic pain with you. As chronic pain patients are increasingly seeking alternatives to Western medicine (Eisenberg et al. 1998), this anecdotal study was designed as an open trial to collect some pilot data without a control. The study was anecdotal without much plan due to the tight schedule of ...

Intracranial aspergillosis is rare in immunocompetent patients. Extension to the cranial base via the sphenoid sinus is exceptional. Authors report a case of middle cranial fossa aspergillosis involving the cavernous sinus and mimicking an extra-axial tumor in an immunocompetent 65 year-old male. The patient had been suffering from left trigeminal neuralgia and a horizontal diplopia since 4 mon...