نتایج جستجو برای: chlorambucil
تعداد نتایج: 2068 فیلتر نتایج به سال:
In 1980, the French Cooperative Group on Chronic Lymphocytic Leukemia started a randomized clinical trial in which intermediate prognosis patients (stage B) received either an indefinite course of chlorambucil (0.1 mg/kg/d) or 12 cycles of the COP regimen (vincristine, cyclophosphamide, and prednisone). We present the results of the third interim analysis based on 291 patients (151 in the chlor...
Obinutuzumab is a novel glycoengineered type II anti-CD20 monoclonal antibody with a higher affinity for CD20 epitope, enhanced antibody-dependent cellular cytotoxicity and direct cell death, leading to superior cytotoxicity compared with rituximab. The approval of obinutuzumab by US Food and Drug Administration was based on a pivotal, phase III, randomized trial of chlorambucil monotherapy (n=...
Currently, nanotechnology is considered a promising strategy to enhance drug solubility and other physicochemical properties. Albumin biopolymer that can be used in delivery systems due its biodegradability biocompatibility. The aim of this study was prepare characterize albumin nanoparticles with chlorambucil as controlled system. Different concentrations were incubated bovine serum (BSA) orde...
Chronic lymphatic leukemia (CLL) is often associated with nephritic syndrome. Effective treatment of CLL by chlorambucil and bendamustine leads to the restoration of renal function. In this contribution, we sought to elucidate the impact of organic anion transporters (OATs) on the uptake of bendamustine and chlorambucil as a probable reason for the superior efficacy of bendamustine over chloram...
purpose : cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of behçet’s disease (bd). the purpose of this study was to evaluate the outcome of eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. methods : chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. prednisolone was concomita...
PURPOSE To assess the efficacy and side effects of immunosuppressive therapy in patients with Behçet's disease uveitis. METHODS A nonrandomized retrospective case-series study analyzed data from 22 patients with Behçet's disease uveitis, from a single Uveitis Service, São Paulo, Brazil (period 1978-2007), under systemic chlorambucil and/or cyclosporine A, for at least 6 months with a minimum ...
We have examined the influence of chlorambucil, a bifunc tional alkylating agent that inhibits cell proliferation, on DNA replication and histone gene expression in exponentially grow ing HeLa S3 cells. During the period of treatment with chlor ambucil (up to 3 days), neither transcription nor translation in general appeared to be affected, but the incorporation of [14C]thymidine into DNA was r...
BACKGROUND Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide. We aimed to establish whether this treatment combination provided greater survival benefit than did chlorambucil or fludarabine. METHODS 777 patients with chronic lymphocytic leukaemia requiring treatment were randomly assigned to fludarabine (...
Five patients with Behcet's disease in the active and progressive stages were treated with chlorambucil (Leukeran). In all aptients a long-lasting remission was obtained, the ocular lesions did not progress and the vision did not deteriorate. Follow-up varied between 10 and 24 months. Results were encouraging and the form of treatment with chlorambucil and small doses of corticosteroids was sup...
Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholesterol content, cholesterol/phospholipid ratio, and the lymphocyte subpopulations....
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