A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9-86 p...

Idiopathic Systemic Capillary Leak Syndrome is a potentially fatal disorder that is under diagnosed. It commonly presents as recurrent undifferentiated shock with hypotension, hypoalbuminemia and hemoconcentration. There are three distinct phases that define the syndrome; Prodromal, Extravasation and Recovery.

INTRODUCTION Systemic capillary leak syndrome is a rare and life threatening disease characterized by periodic episodes of hypovolemic shock due to leakage of plasma from the intravascular to the extravascular space. It is associated with hemoconcentration, hypoalbuminemia, and generalized edema. We report the case of a patient with idiopathic systemic capillary leak syndrome who developed an u...

Quisiera agradecer a los doctores M. Molina, R. Amézaga, A. Colomar y M. Riera del Servicio de Medicina Intensiva, Hospital Universitario Son Espases, Palma de Mallorca, España, sus felicitaciones en relación con el artículo publicado en su revista «Guías de práctica clínica para el manejo del síndrome de bajo gasto cardíaco en el postoperatorio de cirugía cardíaca»1 por sus palabras, al consid...

Gemcitabine (Gemcitabine), a synthetic pyrimidine nucleoside, could block DNA synthesis and inhibit RNA synthesis to some extent. It is used as the standard chemotherapy for pancreatic adenocarcinoma in stage II, III and IV, although it’s primarily palliative (Lau et al., 2012). As a severe result of the attack by gemcitabineinduced cytotoxicity for capillary endothelial cells (CECs), capillary...