A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to differential scanning calorimetry. Cod liver oil entrapped calcium alginate beads containing famotidine, capable of floating in...

Biocompatible polymer solutions that can crosslink in situ following injection to form stable hydrogels are of interest as depots for sustained delivery of therapeutic factors or cells, and as scaffolds for regenerative medicine. Here, injectable self-gelling alginate formulations obtained by mixing alginate microspheres (as calcium reservoirs) with soluble alginate solutions were characterized...

Alginate gel crosslinked by calcium ions (Ca(2+)) has been widely used in cartilage tissue engineering. However, most studies have been largely performed in vitro in medium with a calcium concentration ([Ca(2+)]) of 1.8mM, while the calcium level in the synovial fluid of the human knee joints, for example, has been reported to be 4mM or even higher. To simulate the synovial environment, the two...

The present work aimed to increase the thermostability and pH stability of lipase produced from Penicillium chrysogenum SNP5 using different anionic carriers. The immobilized lipase from the fungus on 1.25% sodium alginate beads and 12% polyacrylamide beads retained 37.28 and 59.75% immobilization efficiency, respectively, on 3 mm bead size. Immobilized lipase on calcium alginate and polyacryla...

This study reports an industrially applicable non-sterile xylitol fermentation process to produce xylitol from a low-cost feedstock like corn cob hydrolysate as pentose source without any detoxification. Different immobilization matrices/mediums (alginate, polyvinyl alcohol, agarose gel, polyacrylamide, gelatin, and κ-carrageenan) were studied to immobilize Candida tropicalis NCIM 3123 cells fo...

In this paper, the manipulation of monodisperse Ca-alginate microparticles using a microfluidic chip and a reaction of internal gelation is presented. Our strategy is based on the sheath focusing effect to form uniform water-in-oil (w/o) emulsions in the cross-junction microchannel. These fine emulsions, consisting of 1.5 % w/v Na-alginate and 1.0 % w/v calcium carbonate, are then dripped into ...

We developed a novel fabrication technique of titania microspheres utilizing a robust external gelation method on an oil/hydrogel interface. By putting sodium alginate droplets on an interface between oil and Ca 2+ -loaded hydrogel, surfactant dissolved in oil forms amphiphilic bilayer. Water molecules and calcium ions transfer through this amphiphilic bilayer. As a result, alginate droplets sh...

The present investigation was designed to develop, characterize and evaluate mucoadhesive microcapsules of isoniazid employing various mucoadhesive polymers for prolonged gastric intestinal absorption. Sodium alginate is an anionic polymer which can be easily cross-linked with calcium chloride. This is because the calcium ions are bound to carboxylate residues of both mannuronic acid and glucou...

BACKGROUND This experimental study compared the hemostatic effects of calcium alginate and Anka-ferd Blood Stopper in hepatic parenchymal bleedings. MATERIAL AND METHOD The study comprised 39 male Wistar albino rats (weight 230±30 g). Laceration model was created in the left lateral lobe of the liver. Standard cotton gauze that was impregnated 0.9% NaCl solution and Calcium alginate cover was...

BACKGROUND We have previously shown that suspension culture prevents follicle flattening and maintains three-dimensional follicle architecture better than culture on flat plates. However, many of the follicles cultured in suspension do eventually rupture, as basement membrane integrity is lost and the three-dimensional structure of the follicle is altered. Therefore, the objective of this study...