Until relatively recently, the field of drug design and development was disconnected from advances in computing and informatics. Without even considering the concept of computing, previous generations of scientists and clinicians had great motivation to examine the symptoms of ill or injured patients, infer from sufficient observation data about the causes of their symptoms, and search for chem...

Systems biology is a burgeoning field in which researchers are investigating a flood of new data that is gathered in highthroughput genomics, proteomics, and related analyses. Systems biologists focus on what this data reveals about the functioning of living systems. The large volume of data, and the complexity of living systems, ensures that computing plays a central role in analyzing, modelin...

Synthetic biology and biomolecular computation are disciplines that fuse when it comes to designing and building information processing devices. In this chapter, we study several devices that are representative of this fusion. These are three gene circuits implementing logic gates, a DNA nanodevice and a biomolecular automaton. The operation of these devices is based on gene expression regulati...

Systems constructed from vast numbers of tiny processors / sensors, connected together in a nonprescribed way, form the basis of novel computing paradigms such as amorphous computing, ubiquitous computing and pervasive computing. Within these systems, the individual computational units may be fragile, unpredictable and only able to communicate locally. However, despite these individual restrict...

In recent years, several works have demonstrated how the study of biology can benefit from an algorithmic perspective. Since biological systems are often distributed in nature, this approach may be particularly useful in the context of distributed computing. As the study of algorithms is traditionally motivated by an engineering and technological point of view, the adaptation of ideas from theo...

The eight papers in this special section were presented at the Sixteenth International Conference on Intelligent Computing (ICIC) that was held Bari, Italy, October 2-5, 2020. ICIC formed to provide an annual forum dedicated emerging and challenging topics artificial intelligence, machine learning, bioinformatics, computational biology, etc. It aims bring together researchers practitioners from...

This article traces one important trajectory in the history of expert systems. Through a collaboration between Edward Feigenbaum and geneticist Joshua Lederberg, Nobel Laureate Medicine, AI became deeply connected to life sciences. Biology was crucial test bed for some Feigenbaum's systems and, long term, these had transformative effect on biology. In particular, work his collaborators students...

Welcome to The 2009 International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (IJCBS’09) being held in Shanghai, China on August 3-5, 2009. Bioinformatics, Systems Biology and Intelligent Computing are synergistic disciplines that hold great promise for the advancement of research and development in designing intelligent systems to solve systems biology and tr...