Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide. Despite extensive investigations over the past few decades, no effective therapies exist to improve the brain function in patients with TBI. Neural tissue engineering is an attractive therapeutic approach to restore the brain structure and function of damaged tissue. Bioactive motif of Stromal cell-deri...

Elektrokinetické vlastnosti zmesí minerálov Elektroforetický rozptyl svetla (ELS) je nová experimentálna technika umožňujúca merať spectrum elektroforetickej pohyblivosti alebo zeta (ξ) potenciálu skupiny častíc. Toto spectrum odráža distribúciu náboja a čiastočne distribúciu rozmeru týchto častíc. Avšak, okrem modálnej hodnoty napr. zeta potenciálu častíc rovnakého druhu, z ELS spektra môžeme ...

Many secreted bioactive signaling molecules, including the yeast mating pheromones a-factor and alpha-factor, are initially synthesized as precursors requiring multiple intracellular processing enzymes to generate their mature forms. To identify new gene products involved in the biogenesis of a-factor in Saccharomyces cerevisiae, we carried out a screen for MA Ta-specific, mating-defective muta...

Many secreted bioactive signaling molecules, including the yeast mating pheromones a -factor and a -factor, are initially synthesized as precursors requiring multiple intracellular processing enzymes to generate their mature forms. To identify new gene products involved in the biogenesis of a -factor in Saccharomyces cerevisiae , we carried out a screen for MAT a -specific, mating-defective mut...

Many bioactive natural products are produced as "secondary metabolites" by plants, bacteria, and fungi. During the middle of the 20th century, several secondary metabolites from fungi revolutionized the pharmaceutical industry, for example, penicillin, lovastatin, and cyclosporine. They are generally biosynthesized by enzymes encoded by clusters of coordinately regulated genes, and several moti...

The Ar-CF2H moiety is featured in an increasing number of bioactive compounds due to its unique combination properties. hydrodefluorination Ar-CF3 a direct and efficient route toward this motif. As reported methods for transformation have focused on specific substrate families, herein we describe general—electronically ambivalent—procedure the single-step mono-hydrodefluorination variety feedst...

1,2,3,4-Tetrahydroisoquinolines form a valuable scaffold for variety of bioactive secondary metabolites and commercial pharmaceuticals. Due to the harsh or complex conditions conventional chemical synthesis this molecular motif, alternative mild reaction pathways are in demand. Here we present an easy-to-operate chemoenzymatic one-pot process tetrahydroisoquinolines starting from benzylic alcoh...

milk proteins provide a natural source of bioactive peptides with potential health benefits and applications in the food industry. the release of these peptides from milk proteins is achieved either by hydrolysis using digestive proteases or by lactic acid bacteria fermentation. peptides, particularly those derived from milk proteins, can exert a wide range of nutritional, functional and biolog...