Background: Involvement of Wnt proteins and one of its antagonist known as secreted Frizzled Related Protein type-4 (sFPRP-4) was reported in rodent ovarian follicular development. Other studies showed an ap- Abstracts of the 11th Royan International Congress on Reproductive Biomedicine 7 7 International Journal of Fertility & Sterility (IJFS), Vol 4, Suppl 1, Summer 2010 optotic-associated exp...

Introduction: In the present study, we assessed the effects of β-carotene on Titanium oxide Nanoparticle (TNP) induced mouse Spermatozoon Stem Cells (SSCs) apoptosis, at molecular level.  Methods: After isolation from cryptorchid mouse testis and characterization, spermatogonial stem cells were divided into four groups. In the control group, spermatogonial cells were cultured in &alp...

Multiple sclerosis (MS) is an inflammatory autoimmune disease which is presented by environmental factors and genetic predisposition, increasingly affecting a large number of people worldwide. CNS inflammation is a local tissue response to stimulants and is characterized by induction of cytokines, chemokines and vascular permeability. Our goal in this study is to understand the micro-environmen...

Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...

Background: β-thalassemia is one of the most widespread disease in the world, including Iran. In this study, we reported, for the first time, A 290-bp β-globin gene deletion in the south of Iran. Methods: Four individuals from three unrelated families with Arabic ethnic background were studied in Khuzestan Province. Red blood cell indices and hemoglobin analysis were carried out accor...

Background and Aims: Several studies have shown that there is greater number of viruses in deep periodontal pockets than in normal gingival sulcus. We also know that virus may have an important role in induction of Il-1β secretion by different human cells. In this study we intended to determine the capacity of Herpes simplex virus type 1 to stimulate Il-1β secretion in human gingival ...

Background Luteinizing hormone (LH) is a heterodimeric glycoprotein composed of alpha and beta subunits.This hormone is secreted from the pituitary gland. LH, in women triggers Menstrual cycle and ovulation. In men, LH stimulates production of testosterone, which plays a specialized role in sperm production. Up to day, LH hormone have produced in different ways such as codon optimization and al...