Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin concentration in aqueous humor was 3% of that in plasma. One hour after paracen...

FOR many years considerable attention has been focused on the problem of the origin and circulation ofthe aqueous humour under normal and pathological conditions. One of the methods applied to this study is the detection within the eye of dyes which enter the anterior chamber across the bloodaqueous baffler-a method first suggested by Ehrlich (1882) when he observed that fluorescein injected in...

Ocular penetration of 5-fluorocytosine (5FC) was studied in uninfected rabbits after subconjunctival and oral administration. With oral administration, 5FC achieved therapeutic levels in both the vitreous and aqueous humors. The use of a pharmacokinetic model permitted objective comparison of kinetic events within the eye chambers and the serum. The rates of entry and elimination in the vitreou...

EARLY analyses of the proteins of the normal aqueous humour by Franceschetti and Wieland (1928), and later by Kronfeld (1941) and Kronfeld and others (1941), have shown a content of 10 to 20 mg. per cent. Any functional significance this protein may have is unknown. However, the human lens contains 30-40 p' r cent. protein, the fractions of which have been determined by several authors (Cagianu...

The intraocular and systemic blood pressure, height, weight, and haemoglobin were measured in 573 subjects over 60 years old from a general practice population. Intraocular pressure was positively and independently related to systemic blood pressure (P less than 0.0001) and obesity (P less than 0.01) as assessed by the ponderal index. Systolic pressure rather than diastolic or mean pressure was...

Humor is hypothesized to be a social activity that alters the status of the humorist positively and that of the object or victim negatively. Of the two traditionally distingushed classes of humor, "ostracizing" humor singles out a victim, with others present or absent either incidental affiliates of the humorist (and one another) or unaffected. "AltBiative" humor, on the other hand, is focused ...

“SEM images were acquired at Frederick Seitz Materials Research Laboratory Central research facilities, UIUC. Funding: We acknowledge University of Illinois at Urbana-Champaign and Children’s Discovery Institute for financial assistance. Authors would like to gratefully acknowledge the kind support from Prof. Gang Logan Liu, ECE, UIUC and his laboratory for allowing us to use his inbuilt maskin...

Fluoresceinated IgG was injected centrally into the rabbit's cornea and both its rate of loss from the tissue and its rate of spread in the stroma were estimated by objective fluorometry. A new technique for determining the rate of loss was established which required only the measurement of the maximum fluorescence in the tissue. The rate at which freshly formed IgG in the blood would arrive at...

The effects of topical application of the carbonic anhydrase inhibitor trifluormethazolamide (TFM) on intraocular pressure (IOP), ascorbate and CO2 concentrations in aqueous humor, and aqueous humor flow were studied in rabbits. These effects were compared with those produced by systemic treatment with methazolamide. The decrease in IOP observed after TFM was accompanied by changes in the compo...