نتایج جستجو برای: apobec3g

تعداد نتایج: 713  

Journal: :The Journal of biological chemistry 2010
Yukie Iwabu Masanobu Kinomoto Masashi Tatsumi Hideaki Fujita Mari Shimura Yoshitaka Tanaka Yukihito Ishizaka David Nolan Simon Mallal Tetsutaro Sata Kenzo Tokunaga

Antiretroviral cytidine deaminase APOBEC3G, which is abundantly expressed in peripheral blood lymphocytes and macrophages, strongly protects these cells against HIV-1 infection. The HIV-1 Vif protein overcomes this antiviral effect by enhancing proteasome-mediated APOBEC3G degradation and is key for maintaining viral infectivity. The 579-bp-long vif gene displays high genetic diversity among HI...

Journal: :The Journal of Experimental Medicine 2006
Gang Peng Ke Jian Lei Wenwen Jin Teresa Greenwell-Wild Sharon M. Wahl

Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G), a cytidine deaminase, is a recently recognized innate intracellular protein with lethal activity against human immunodeficiency virus (HIV). Packaged into progeny virions, APOBEC3G enzymatic activity leads to HIV DNA degradation. As a counterattack, HIV virion infectivity factor (Vif) targets APOBEC3G for proteasomal...

Journal: :The Journal of general virology 2007
Chiemi Noguchi Nobuhiko Hiraga Nami Mori Masataka Tsuge Michio Imamura Shoichi Takahashi Yoshifumi Fujimoto Hidenori Ochi Hiromi Abe Toshiro Maekawa Hiromi Yatsuji Kotaro Shirakawa Akifumi Takaori-Kondo Kazuaki Chayama

G to A hypermutation of Hepatitis B virus (HBV) and retroviruses appears as a result of deamination activities of host APOBEC proteins and is thought to play a role in innate antiviral immunity. Alpha and gamma interferons (IFN-alpha and -gamma) have been reported to upregulate the transcription of APOBEC3G, which is known to reduce the replication of HBV. We investigated the number of hypermut...

Journal: :Current Biology 2004
Mark T. Liddament William L. Brown April J. Schumacher Reuben S. Harris

APOBEC3G (CEM15 ) deaminates cytosine to uracil in nascent retroviral cDNA. The potency of this cellular defense is evidenced by a dramatic reduction in viral infectivity and the occurrence of high frequencies of retroviral genomic-strand G --> A transition mutations. The overwhelming dinucleotide hypermutation preference of APOBEC3G acting upon a variety of model retroviral substrates is 5'-GG...

Journal: :ACS chemical biology 2012
Ming Li Shivender M D Shandilya Michael A Carpenter Anurag Rathore William L Brown Angela L Perkins Daniel A Harki Jonathan Solberg Derek J Hook Krishan K Pandey Michael A Parniak Jeffrey R Johnson Nevan J Krogan Mohan Somasundaran Akbar Ali Celia A Schiffer Reuben S Harris

APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate immune response to viruses and transposons. Although APOBEC3G is the prototype for understanding the larger mammalian polynucleotide deaminase family, no specific chemical inhibitors exist to modulate its activity. High-throughput screening identified 34 compounds that inhibit APOBEC3G catalytic activity. Twe...

Journal: :Journal of virology 2006
Craig Pace Jean Keller David Nolan Ian James Silvana Gaudieri Corey Moore Simon Mallal

APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G-->A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known. Here, we describe a population level analysis of HIV-1 hypermutation in [corrected] clade B proviral DNA sequences (n = 127). G-->A hypermutation conforming t...

Journal: :RNA 2008
Hal P Bogerd Bryan R Cullen

Binding of APOBEC3G to the nucleocapsid (NC) domain of the human immunodeficiency virus (HIV) Gag polyprotein may represent a critical early step in the selective packaging of this antiretroviral factor into HIV virions. Previously, we and others have reported that this interaction is mediated by RNA. Here, we demonstrate that RNA binding by APOBEC3G is key for initiation of APOBEC3G:NC complex...

Journal: :Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009
Michael H Malim

Members of the APOBEC family of cellular polynucleotide cytidine deaminases, most notably APOBEC3G and APOBEC3F, are potent inhibitors of HIV-1 infection. Wild type HIV-1 infections are largely spared from APOBEC3G/F function through the action of the essential viral protein, Vif. In the absence of Vif, APOBEC3G/F are encapsidated by budding virus particles leading to excessive cytidine (C) to ...

2012
Torsak Bunupuradah Mayumi Imahashi Thatri Iampornsin Kazuhiro Matsuoka Yasumasa Iwatani Thanyawee Puthanakit Jintanat Ananworanich Jiratchaya Sophonphan Apicha Mahanontharit Tomoki Naoe Saphonn Vonthanak Praphan Phanuphak Wataru Sugiura

INTRODUCTION Human APOBEC3G is a host defense factor that potently inhibits HIV replication. We hypothesize that HIV-infected children with a genetic variant of APOBEC3G will have a more rapid disease progression. METHODS Antiretroviral therapy (ART)-naïve children, aged 1-12 years old with CD4 15-24% and without severe HIV-related symptoms were enrolled. The children had CD4% and absolute CD...

2012
Eric W. Refsland Judd F. Hultquist Reuben S. Harris

The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity and the associated problems of drug resistance and immune escape. APOBEC3G exhi...

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