Interaction of the antipsychotic drugs with dopamine receptors of the D2, D3, or D4 subclasses is thought to be important for their mechanisms of action. Consideration of carefully defined affinities of the drugs for these three receptors suggests that occupancy of the D4 subclass is not mandatory for achieving antipsychotic effects, but actions at D2 or D3 receptors may be important. A major d...

Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen of rat brain. Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 muM dopamine at micromolar concentrations. Among 14 other structurally ...

Introduction The use of antipsychotics in the treatment mentally ill represents a complex modality, especially specialized institutions such as Institute Forensic Psychiatry Kosovo. Current best practices are summarized clinical guidelines, which nevertheless recognize importance individualizing treatment. In literature there is scarcity knowledge on effectiveness pharmacological within forensi...