A relationship between antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and complement has been shown, and complement has an important role in the pathogenesis of AAV. The clinical characteristics of AAV with hypocomplementemia still remain unclear.We conducted an observational study of 81 patients with AAV (median onset age 71 years; 58% female). Using medical records, ...

Dear Sir,COVID-19 is of paramount concern in the rheumatology community. As per current consensus, patients rheumatological diseases (RDs) are at higher risk SARS-CoV-2 infection than general population (high agreement but very low grade evidence); however, contradictory reports available regarding its seroprevalence and association with severity mortality. However, these inferences mainly base...

BACKGROUND Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is highly associated with inflammatory bowel disease (IBD). Certain PG patients with no systemic disorders have been diagnosed with idiopathic PG. This study sought to clarify the difference between PG with IBD and idiopathic PG based on clinical features, laboratory tests, and medications. METHODS Twelve patients wit...

background: patients with ulcerative colitis (uc) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-anca). objective: the aim of the present study was to evaluate the target antigens for p-anca in iranian patients with uc. methods: p-anca target antigens including elastase, lactoferrin, cathepsin g, myeloproxidase, lysozyme, and bactericidal permeability increasi...

* Author for correspondence: Professor Sharique Ahmed, Allied Health Division, College of Health Sciences, Kingdom of Bahrain. Email [email protected]. Abstract. Alpha-1-antitrypsin is an acute phase protein which is up-regulated in acute phase responses to tissue necrosis and inflammation. It belongs to a class of inhibitors called ‘’Serpins’’ (serine protease inhibitors). Human plasma con...

BACKGROUND/AIMS Churg-Strauss syndrome (CSS) is a rare systemic necrotizing small-vessel vasculitis, with accompanying bronchial asthma, eosinophilia, and eosinophilic infiltration of various tissues. The purposes of our study were to characterize the clinical features of CSS and to identify factors associated with CSS prognosis in Koreans. METHODS Medical records were reviewed retrospectivel...

The systemic vasculitides are characterized by inflammation of blood vessel walls. Vessels of any type, in any organ can be affected, resulting in a broad spectrum of signs and symptoms. The heterogenous nature of vasculitides presents a diagnostic challenge. The American College of Rheumatology classification criteria and the Chapel Hill Consensus Conference nomenclature are the most widely us...

On rare occasions, patients with Goodpasture’s syndrome (GPS) present both anti-glomerular basement membrane (GBM) and antineutrophil cytoplasmic antibody (ANCA). Concurrent ANCA anti-GBM disease is a high mortality rate. Here we case of (ANCA) complicated hyponatremia.

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare condition that can cause rapid renal failure. Treatment involves steroids and other immunosuppressive agents. Agents for induction include rituximab, cyclophosphamide, pulse dose avacopan.