Various soil samples were randomly collected at different places in south Delta, Egypt. A total of 105 Streptomyces isolates, were selected according to their morphological characteristics. Antifungal activity was assessed by agar well diffusion assay. Ten isolates showed antifungal activity against various reference strains of yeast and fungi. The maximum zone of inhibition was detected for As...

Aim: This study was performed to isolate antifungal substance from actinomycetes species found in soil in order to avoid osmophilic food spoilage. Methods: Purified isolates of different actinomycetes collected from soil in Makkah region, Saudi Arabia were screened for their antifungal bioactivity against the unicellular fungal strain, Saccharomyces cerevisiae. The actinomycete isolate that sho...

Collybia nivalis, Favolaschia sp. 87129, Pterula sp. 82168 and Omphalotus olearius were cultivated on natural substrates. The antibiotic metabolites oudemansin A. strobilurins A, D, illudin S and pterulone were isolated and identified. A new antifungal metabolite, pterulone B, was described from cultures of Pterula sp. 82168 on wood. Collybia nivalis was found to be the first species of this ge...

A strong antifungal and antitumor agent, 24-demethylbafilomycin C1 (1) has been isolated from Streptomyces sp. CS1). The structure of 1 is different from those of bafilomycins at the replacement of the isopropyl group with ethyl group at C-23, and different from hygrolidins at C-2 substitution and the orientations of the substituents at C-21, C-22 and C-23 in the pyranose ring2-5). Therefore it...

Production of chlorflavonin, a new antifungal antibiotic, by strains of Aspergillus candidus is described. Two wild strains of the fungus had distinctly different chlorflavonin-producing capabilities. One strain produced 25 mug of chlorflavonin per ml per 4 to 5 days in a pilot scale fermentor with stirring, using a medium containing corn steep liquor and glucose. Production of antibiotic was f...

Cyanobacteria are a group of oxygenic photosynthetic prokaryotes found in almost all habitats on earth including those characterized as extreme environments. It has been observed that the number studies dealing with biodiversity extremophilic cyanobacteria is limited while exploring their bioactive potential even scarcer. The taxonomy three Nostoc-like cyanobacterial strains isolated from shall...

Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly i...

A 3-decalinoyltetramic acid, for which the trivial name hymenosetin is proposed, was isolated from crude extracts of a virulent strain of the ash dieback pathogen, Hymenoscyphus pseudoalbidus (="Chalara fraxinea"). This compound was produced only under certain culture conditions in submerged cultures of the fungus. Its planar structure was determined by NMR spectroscopy and by mass spectrometry...

MALDI mass spectrometry imaging was performed to localize metabolites during the first seven days of the barley germination. Up to 100 mass signals were detected of which 85 signals were identified as 48 different metabolites with highly tissue-specific localizations. Oligosaccharides were observed in the endosperm and in parts of the developed embryo. Lipids in the endosperm co-localized in de...