INTRODUCTION Antiepileptic drugs, which are also called anticonvulsants, are used in the therapy and prophylaxis of epileptic seizures. The purpose of this paper was to investigate the relevant epidemiological data and to determine which of these drugs was the most frequent cause of intoxication. Another purpose of this study was to determine the neurological, cardiac, and biochemical problems ...

Although aromatic anticonvulsants are usually well tolerated, they can cause cutaneous adverse drug reactions in up to 10% of patients. The clinical manifestations of the antiepileptics-induced hypersensitivity reactions (AHR) vary from mild skin rashes to severe cutaneous drug adverse reactions which are related to high mortality and significant morbidity. Genetic polymorphisms in cytochrome P...

During early 1990s, there were 30 million patients with epilepsy in the world1. They require long-term medication with various antiepiletic formulations. The efficacy of various therapeutic formulations being offered to those suffering from an epileptic disorder (Table 1) could be severely lowered in the face of impending global warming and frequent occurrence of the El niño effects. Even thoug...

Osteoporosis (OP) and fragility fractures (FFx) are a known comorbidity in patients with systemic lupus erythematosus (SLE). This work aimed at evaluating (1) the prevalence of OP and FFx in a cohort of SLE and (2) the risk factors associated with both OP and FFx. The following data were collected from clinical charts: age, sex, menopausal status (MP), body mass index, smoking habits, disease d...

Antiepileptics are a very important class of medications, and the number of these drugs available for clinical use has increased dramatically in the last decade. The pharmacology and indications for use in a variety of physiatric patient groups are comprehensively and systematically reviewed.

BACKGROUND Postherpetic neuralgia (PHN) is a nerve pain disease usually controlled by different therapies, i.e., topical therapies, antiepileptics, analgesics, antipsychotics, antidepressants, anti-dementia drugs, antivirals, amitriptyline, fluphenazine, and magnesium sulfate. It is believed that different therapies may lead to different levels of pain relief. OBJECTIVES We proposed this stud...

OBJECTIVE To determine whether use of antiepileptic drugs during pregnancy may increase the risk of spontaneous abortion or stillbirth. DESIGN Population based cohort study. SETTING Register based study in Denmark, 1997-2008. PARTICIPANTS 983,305 pregnancies identified in the Danish medical birth register and the Danish national hospital discharge register from 1 February 1997 to 31 Decem...

Background: Carbamazepine (CBZ) is an effective antiepileptic drug (AED) used as first line of for partial and convulsive generalized epilepsy in all age groups. Most common clinically reported side effect CBZ blurry or double vision. How it affects retinal histological architecture has not been explored yet. Aim: To observe the light microscopic changes adult Wistar albino rats after administr...