associations of some hematological and lymphatic diseases with sex and abo and rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in tehran. highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplas...

acute lymphocytic leukemia cells to the level seen in 6C3HED mouse lymphoma. Asparagine requirement by other leukemic cells was inconsistent, and only four of 12 reached the level seen in acute lymphocytic leukemia. No other amino acid studied substituted for asparagine. Omission of asparagine, however, did not lower the uptake to the levels seen upon omission of cysteine, glutamine, histidine,...

acute lymphocytic leukemia cells to the level seen in 6C3HED mouse lymphoma. Asparagine requirement by other leukemic cells was inconsistent, and only four of 12 reached the level seen in acute lymphocytic leukemia. No other amino acid studied substituted for asparagine. Omission of asparagine, however, did not lower the uptake to the levels seen upon omission of cysteine, glutamine, histidine,...

By CHARLES A. HALL With the technical assistance of Alexander E. Finkler, Edward S. Allen and Booker T. Moore T HE PLASMA vitamin B12 is abnormally high in chronic myelocytic leukemia.’8 It is sometimes increased above normal in polycythemia vera35 and myeloid metaplasia,35 but usually not as strikingly so. The plasma vitamin B12 is normal in chronic lymphocytic leukemia,12’4’5’8 lymphoma,4’5’8...

By DANE R. BOGGS T HE NATURE of the defect in host defense mechanisms resulting in the increased incidence of bacterial infection in the leukemias is ill defined. Studies of antibody formation indicate that the patient with an acute leukemia or with chronic myelocytic leukemia has normal or near normal response to antigenic stimulation, whereas the patient with chronic lymphocytic leukemia freq...

To show whether direct proteolysis of coagulation factors may play a role in patients with so-called consumption coagulopathy, granulocytic neutral proteases in the plasma of patients with acute myelocytic leukemia and septicemia were assayed by one- and two-dimensional Laurell electrophoresis. Complexes between serum alpha1-antitrypsin and elastase-like granulocytic protease could be demonstra...

The recent finding that retinoic acid induces terminal granulocytic differentiation of the human promyelocytic leukemia cell line, HL-60, prompted an investigation of the sensitivity to this inducer of human myelocytic leukemia cells in primary suspension culture. Of the 21 leukemic specimens, only cells from the two patients with acute promyelocytic leukemia differentiated in response to retin...

A previously uncharacterized human B-lymphocyte antigen has been detected by rabbit antisera raised to papain digests of spleen cell membranes. The unabsorbed sera reacted in both cytotoxicity and immunofluorescent tests with normal B lymphocytes and cultured B-cell lines but not with normal T lymphocytes or cultured T-cell lines. The cytotoxicity titers against B cells were as high as 1:32,000...

By DANE R. BOGGS T HE NATURE of the defect in host defense mechanisms resulting in the increased incidence of bacterial infection in the leukemias is ill defined. Studies of antibody formation indicate that the patient with an acute leukemia or with chronic myelocytic leukemia has normal or near normal response to antigenic stimulation, whereas the patient with chronic lymphocytic leukemia freq...

By DANE R. BOGGS T HE NATURE of the defect in host defense mechanisms resulting in the increased incidence of bacterial infection in the leukemias is ill defined. Studies of antibody formation indicate that the patient with an acute leukemia or with chronic myelocytic leukemia has normal or near normal response to antigenic stimulation, whereas the patient with chronic lymphocytic leukemia freq...