Understanding accumulated damage effects is essential when undertaking deep underground rock engineering, as complex in situ environments and intense engineering disturbances realistically affect the physical mechanical properties of rocks. Accumulated mainly causes extension micro-cracks sprouting specific defects rocks, altering microstructural parameters. In this investigation, loading unloa...

This research work is topical since there are a lot of objects accumulated environmental damage (AED) in the Russian Federation and task to eliminate them fixed country legislation. These typically brownfields, abandoned industrial building or constructions, waste disposal landfills etc. In accordance with “General cleaning” Federal project we have developed methodical approaches assessing impa...

A theoretical model of He ion imaging for acquisition of a stack of image slices with applications in 3D tomography previously showed that ion implantation accumulates with each image scan [1]. The accumulated ion implantation can result in damage to the target depending on image dose per slice and slice thickness. The imaging ion energy and incidence angle will also influence the accumulated i...

I will first discuss how all aging models that assume that the aged cell has irreversibly lost its youthful capabilities through such mechanisms as accumulated dysfunction, accumulated damage, and/or accumulation of toxic byproducts of metabolism have been shown to be incorrect. I will then briefly discuss models of aging and propose an experiment that would distinguish between those models and...

The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in dam...