نتایج جستجو برای: abca1

تعداد نتایج: 1947  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Miranda van Eck I Sophie T Bos Wolfgang E Kaminski Evelyn Orsó Gregor Rothe Jaap Twisk Alfred Böttcher Edwin S Van Amersfoort Trudy A Christiansen-Weber Wai-Ping Fung-Leung Theo J C Van Berkel Gerd Schmitz

The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a key regulator of high-density lipoprotein (HDL) metabolism, which is defective in familial HDL-deficiency syndromes such as Tangier disease. ABCA1 functions as a facilitator of cellular cholesterol and phospholipid efflux, and its expression is induced during cholesterol uptake in macrophages. To assess the role of...

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2016
Yun-Cheng Lv Yan-Yan Tang Ping Zhang Wei Wan Feng Yao Ping-Ping He Wei Xie Zhong-Cheng Mo Jin-Feng Shi Jian-Feng Wu Juan Peng Dan Liu Francisco S. Cayabyab Xi-Long Zheng Xiang-Yang Tang Xin-Ping Ouyang Chao-Ke Tang

ATP-binding cassette transporter A1 (ABCA1) plays a critical role in maintaining cellular cholesterol homeostasis. The purpose of this study is to identify the molecular mechanism(s) underlying ABCA1 epigenetic modification and determine its potential impact on ABCA1 expression in macrophage-derived foam cell formation and atherosclerosis development. DNA methylation induced foam cell formation...

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ژورنال: Medical Laboratory Journal 2018
Ghanbari-Niaki , Abbas, Hakemi , Shirin, Moghanny Bashi , Mohammad Mehdi, Naghizadeh Qomi , Mehran , Taghipoor Asramy , Amir ,

ABSTRACT           Background and Objectives: The aim of this study was to evaluate the effect of 12 weeks of intense endurance training and bee pollen consumption on ABCA1 gene expression in small intestine, liver and gastrocnemius muscle tissues of male rats.            Methods: In this study, 24 ...

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2017
Alexis Y Carter Florent Letronne Nicholas F Fitz Anais Mounier Cody M Wolfe Kyong Nyon Nam Valerie L Reeves Hafsa Kamboh Iliya Lefterov Radosveta Koldamova

ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive deficits. Abca1 haplo-deficiency in mice expressing human APOE isoforms, increased level of Aβ ol...

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2017
Lagai Ya Zuneng Lu

BACKGROUND ABCA1 R219K single-nucleotide polymorphisms (SNPs) was related to Alzheimer disease (AD) but not Parkinson disease (PD). Here, we analyzed the associations among ABCA1 R219K distribution, serum biomarkers, AD, and PD in a population in northern China. MATERIAL AND METHODS We used the Mini-Mental State Examination (MMSE) and the Hoehn and Yahr scale (H-Y) to evaluate AD and PD progres...

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Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001
A Von Eckardstein C Langer T Engel I Schaukal A Cignarella J Reinhardt S Lorkowski Z Li X Zhou P Cullen G Assmann

Apolipoprotein E (apoE) produced by macrophages in the arterial wall protects against atherosclerosis, but the regulation of its secretion by these cells is poorly understood. Here we investigated the contribution of the adenosine triphosphate binding cassette transporters ABCA1 and ABC8 to the secretion of apoE from either primary human monocyte-derived macrophages (HMDM) or human THP1 macroph...

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Journal: :The Journal of clinical investigation 2001
A K Groen V W Bloks R H Bandsma R Ottenhoff G Chimini F Kuipers

The ABC transporter ABCA1 regulates HDL levels and is considered to control the first step of reverse cholesterol transport from the periphery to the liver. To test this concept, we studied the effect of ABCA1 deficiency on hepatic metabolism and hepatobiliary flux of cholesterol in mice. Hepatic lipid contents and biliary secretion rates were determined in Abca1(-/-), Abca1(+/-), and Abca1(+/+...

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Journal: :Journal of lipid research 2014
Cristina M Ramírez Chin Sheng Lin Kotb Abdelmohsen Leigh Goedeke Je-Hyun Yoon Julio Madrigal-Matute Jose L Martin-Ventura Dat T Vo Philip J Uren Luiz O Penalva Myriam Gorospe Carlos Fernández-Hernando

ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we investigate the potential contribution of the RNA binding protein (RBP) human antigen R (HuR) on the posttranscriptional regulation of ABCA1 expression. ...

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Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Bin Liang Xin Wang Xiaosu Song Rui Bai Huiyu Yang Zhiming Yang Chuanshi Xiao Yunfei Bian

ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in reverse cholesterol transport and exhibits anti-atherosclerosis effects. Some microRNAs (miRs) regulate ABCA1 expression, and recent studies have shown that miR-20a/b might play a critical role in atherosclerotic diseases. Here, we attempted to clarify the potential contribution of miR-20a/b in post-transcriptional regulation o...

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Journal: :Journal of lipid research 2006
Jerzy-Roch Nofer Alan T Remaley Renata Feuerborn Iza Wolinnska Thomas Engel Arnold von Eckardstein Gerd Assmann

It has been suggested that the signal transduction initiated by apolipoprotein A-I (apoA-I) activates key proteins involved in cholesterol efflux. ABCA1 serves as a binding partner for apoA-I, but its participation in apoA-I-induced signaling remains uncertain. We show that the exposure of human fibroblasts to ABCA1 ligands (apolipoproteins and amphipathic helical peptides) results in the gener...

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