There are many types of HPV ranged from 100-150 with distinct regional predeliction and specific histopathology. Although any age group can be affected but plane warts occur mostly in children and young adults. Treatment of verrucae in children is difficult, may be painful using traditional methods, especially if they are multiple or on the face. The objective of the current study was to compar...

fluorinated pyrimidines appeared in the scientific literature in 1962 alone, it is obvious that the scope of this review must be strictly limited. Therefore, it will be restricted to an account of the studies that have been carried out in human cancer patients, both experimental and for clinical evalua tion, except for a brief introduction that reviews the background of rationale, screening aga...

V iral warts are a common skin disease that occurs in 7% to 10% of the entire population. In most cases, the warts disappear spontaneously within 2 years of their onset, but in about one-third of the cases, the warts recur despite repeated treatment. Treatment for warts includes salicylic acid, podophyllin, bleomycin, 5fluorouracil, laser therapy, interferons, cauterization, cryosurgery, and ot...

Various biochemical studies have been carried out in vitro with Ehrlich ascites car cinoma cells susceptible and resistant to fluorinated pyrimidines. There is no major difference between the two cell lines with respect to the utilization of formate or thy midine for DNA thymine biosynthesis, nor the incorporation of uracil or orotic acid into RNA uracil. The incorporation of formate-C'4 into D...

Pancreatic cancer is one of the most lethal forms of cancer and it is estimated that there will be about 44,000 new cases in US in the year 2011. With 37,600 estimated deaths in 2011, pancreatic cancer is the fourth leading cause of cancer related deaths in US (American Cancer Society, 2011). In spite of numerous efforts, the 5-year survival rate for pancreatic cancer has not improved much for ...

The analgesic effect of 5fluorouracil (5-FU) was analyzed in two experimental tests in mice. Two analgesia test, writhing test and hot plate test have been performed in swiss albino mice. The tested substance used was 5-Fluorouracil, i.p. administered in doses of 10 (Lethal Dose 50/10) and 20 mg/kg body weight (bw) (Lethal dose 50/5), 1 hour before tests. In the writhing test, 5-FU has signifi ...

The effects of the two antitumor drugs vinblastine and 5fluorouracil on the growth of the human tumor cell lines U-118 MG (glioma) and HTh-7 (thyroid cancer) were analyzed. The cells were cultured both as monolayers and as multicellular spheroids and exposed to vinblastine (0.1,1.0, or 10 t¿g/m\) or 5-fluorouracil (10, 100, or 1000 u.g/m\) for 15 min, 2 hr, or 24 hr. The drugs induced growth d...

The isolation and characterization of stable mouse Tlymphoma (549) cell variants which have altered levels of both orotate phosphoribosyltransferase and orotidylate decarboxylase are reported. These clones were selected for resistance to either 6-azauridine or S-fluorouracil, two toxic pyrimidine analogs. The cells of one clone, AU-11, are lo-fold more resistant to 6-azauridine than wild type 5...

Hematoporphyrin [1,3,5,8-tetramethyl-2,4-bis(hydroxyethyl)porphin-6,7-dipropionic acid dihydrochloride derivative] (HPD) is a compound that was studied in a number of laboratories be cause of its cytocidal activity after activation by light. Modification of immune function seen during the photochemotherapeutic studies prompted attempts to determine the effect of HPD on the immune and hemopoieti...

Combination cancer chemotherapy induced toxicity can be associated with combined pharmacogenetic syndromes. Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme involved in the catabolic detoxification of 5fluorouracil (5FU). A heterozygous G . A transition at the 59 splicing donor consensus sequence in intron 14 leading to exon 14 skipping (IVS14+1 G . A, DPYD*2A) with partial loss of...