Cortactin is an F-actin binding protein that activates actin-related protein 2/3 complex and is localized within lamellipodia. Cortactin is a substrate for Src and other protein tyrosine kinases involved in cell motility, where its phosphorylation on tyrosines 421, 466, and 482 in the carboxy terminus is required for cell movement and metastasis. In spite of the importance of cortactin tyrosine...

Department of Geology and Geophysics, University of Minnesota, 421 Washington Ave., SE, Minneapolis, MN 55455, USA Minnesota Supercomputing Institute and Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., SE, Minneapolis, MN 55455, USA c Scuola Internazionale Superiore di Studi Avanzati (SISSA) and INFM DEMOCRITOS National Simulation Center, ...

INTRODUCTION ........................................ 419 GENE ORGANIZATION ........................................ 419 TEMPORAL EXPRESSION OF EARLY GENES ........................................ 420 TRANSCRIPTION CONTROL........................................ 421 ACTIVATION OF TRANSCRIPTION BY ElA 421 Mechanism for E1A Action ........................................ 423 E2F Factor .............

We present the results of a detailed temporal analysis of the bright BL Lac object Mrk 421 using the three available long timing mode observations by the EPIC PN camera. This detector mode is characterized by its long life time and is largely free of photon pile-up problems. The source was found in different intensity and variability states differing by up to more than a factor of three in coun...

We present Hubble Space Telescope (HST) imagery and photometry of the active galaxy Markarian 421 and its companion galaxy 14 arcsec to the ENE. The HST images indicate that the companion is a morphological spiral rather than elliptical as previous ground–based imaging has concluded. The companion has a bright, compact nucleus, appearing unresolved in the HST images. This is suggestive of Seyfe...

The BL Lac object Mrk 421 was observed on May 25, 2000 during the XMM−Newton Cal/PV phase. The high throughput of the X-ray telescopes and the spectral capabilities of the instruments allow an uninterrupted temporal and spectral study of the source with unprecedented time resolution. Mrk 421 was found at a relatively high state with a 2−6 keV flux of (1.3−1.9)×10−10 erg cm−2 s−1. The observed i...

Dagmar Markechová 1,* and Beloslav Riečan 2,3 1 Department of Mathematics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, A. Hlinku 1, SK-949 01 Nitra, Slovakia 2 Department of Mathematics, Faculty of Natural Sciences, Matej Bel University, Tajovského 40, SK-974 01 Banská Bystrica, Slovakia; [email protected] 3 Mathematical Institute, Slovak Academy of Scienc...