نتایج جستجو برای: 3 d pyrimidines
تعداد نتایج: 2219499 فیلتر نتایج به سال:
a new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...
Silica-bonded N-propyldiethylenetriamine sulfamic acid (SPDTSA) is employed as a recyclable heterogeneous solid acid catalyst for the synthesis of benzopyrano[2,3-d]pyrimidines through one-pot condensation reaction of salicylaldehydes, malononitrile and secondary amines at room temperature under solvent-free conditions. SPDTSA showed much the same efficiency when used in con...
In continuation to our research program concerned with structural modification of thieno[2,3-d]pyrimidines with the purpose of enhancing their anticancer activity, various series of hexahydrocycloocta[4,5]thieno[2,3-d]pyrimidin-4-ones, hexahydrocycloocta[4,5]thieno[3,2-e]-1,2,4triazolo[4,3-c]pyrimidine-3(2H)-thiones and 4-substituted hydrazinylhexahydrocycloocta[4,5]thieno[2,3-d]pyrimidines wer...
A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids. To demonstrate the versatility of our method, a representative library of 108 tetrasubstituted pyrrolo[2,3-d]pyrimidines of high quality was synthesized.
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinas...
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