During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to benefit their own growth or invasive capac...

Background—Estrogen is cardioprotective of the coronary circulation by mechanisms incompletely understood. This study determined the effect of chronic 17b-estradiol replacement on dilator responses to acetylcholine and sodium nitroprusside of the isolated coronary microcirculation. Methods and Results—Adult female guinea pigs were ovariectomized, and a 21-day-release pellet containing 0.0, 0.1,...

Due to its 1770 K equilibrium temperature, WASP-17b, a 1.99 $R_\mathrm{Jup}$, 0.486 $M_\mathrm{Jup}$ exoplanet, sits at the critical juncture between hot and ultra-hot Jupiters. We present 0.3-5 $\mu m$ transmission spectrum, with newly obtained Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) measurements, and, taking advantage of improved analysis techniques, reanalysed HST Imaging Spe...

Although the quinoline ring is found in a wide variety of biologically active compounds and is frequently condensed with various heterocycles, synthesis and biological evaluation of the indenoquinoline skeleton attracts only very limited attention. We report herein the synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives against the growth of six cancer cell ...

We previously reported upregulation of UGT2B15 by 17b-estradiol in breast cancer MCF7 cells via binding of the estrogen receptor a (ERa) to an estrogen response unit (ERU) in the proximal UGT2B15 promoter. In the present study, we show that this ERa-mediated upregulation was significantly reduced by two ER antagonists (fulvestrant and raloxifene) but was not affected by a third ER antagonist, 4...

The clinical observation that coronary artery disease is more common in men and postmenopausal women than in premenopausal women has suggested cardioprotective effects of female sex hormones including hormone-mediated coronary vasodilation. The purpose of this study was to investigate whether the sex hormone-induced coronary relaxation is caused by inhibition of Ca mobilization into coronary sm...

the conversion of androst-4-ene-3,17-dione (androstenedione) to estrone through three sequential oxygenations of the 19-methyl group. Inhibitors of aromatase have recently attracted interest not only in the treatment of advanced estrogen-dependent breast cancer but also in the elucidation of the spatial aspects of the active-site of the enzyme as well as the still unsolved mechanism of the arom...