Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. In atherosclerotic lesions, calcification is mainly found in the neointima of atheromatous plaques and has been shown to positively correlate with the plaque burden and the risk of myocardial infarction. Calcification of atherosclerotic plaques has been clearly shown to result from osteoblastic differentia...

Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of tanshinone IIA by cell proliferation assay and cell mi...

Disorders likely ‘inflammatory’ in nature are known to be linked accelerated atherosclerotic processes that increase the chances of cardiovascular disease. Systemic lupus erythematosus (SLE) is a well-known autoimmune disease for its ability affect any organ and cause morbidity. One such major morbidity mortality SLE premature coronary heart Inflammation considered main pathogenesis atheroscler...

Chronic exposure to high glucocorticoid levels in Cushing's syndrome (CS) is often associated with alterations in the hemostatic system and the expression of prothrombotic phenotypes. Increased frequency of both atherothrombotic and venous thromboembolic events (VTE) has been reported in patients with CS. In general, cardiovascular complications in these patients cause a five-fold increase in m...

That diet and the state of the blood lipids are in some way related to the establishment of arteriosclerosis is supported by voluminous epidemiological, clinical, and experimental evidence, but the exact roles of these factors in the pathogenesis of this important disease have not been clarified. In this laboratory, experiments have demonstrated that lipids from the ambient plasma, derived eith...