Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or pla...

The results of many recent experimental and clinical studies support the hypothesis that progesterone administered vaginally is distributed selectively to the uterus where tissue concentrations and effects exceed expectations. This phenomenon has multiple clinical implications in several fields of gynaecological endocrinology, notably in assisted reproductive treatments and new forms of hormone...

The increasing number of breast cancer patients who suffer from menopausal symptoms is mainly due to the extensive use of adjuvant treatments in the younger women. Both short and long-term side effects of oestrogen deficiency may severely impact on the quality of life of these women and should not be underestimated. Hormonal treatments are contraindicated in breast cancer survivors mainly due t...

STRUCTURE AND DERIVATION oric acid, also called boracic acid or orthoboric acid, is an inorganic acid with the chemical formula H3BO3. It is available as a white, odorless powder and in crystalline and granular forms. Bo-ric acid vaginal suppositories are not commercially available and, therefore, must be compounded. Most studies documenting efficacy utilize 600 mg of boric acid powder in a gel...

Our study was conducted to assess the pharmacokinetics of natural progesterone administered in the novel formula of an effervescent vaginal tablet. Fifty post-menopausal women, with a median age of 43.5 years (range 28-55), volunteered to participate in the research. All women discontinued their hormonal replacement therapy 1 month prior to the study. The pharmacokinetics of 50 and 100 mg of pr...

The vagina, unlike other mucoses, is very dynamic with respect to its histology and physiology. This leads to the existence of a long list of factors included in the vaginal environment that affect substances absorption deposited there. Recently, it has been obtained normal ovulation rates in rabbit does inseminated which were induced with an intravaginal dose of GnRH analogue. This text provid...

BACKGROUND The pharmacokinetics of vaginal misoprostol as a dry tablet or as a tablet moistened with normal saline or with acetic acid were studied. METHODS For this study, 42 women requesting termination of pregnancy at gestational age of <12 weeks were recruited and received 400 µg vaginal misoprostol tablets. They were randomized into three groups: (i) dry tablets, (ii) tablets moistened w...

OBJECTIVE To support the practitioner in the diagnosis of vaginal atrophy and in the management of the related symptoms. OPTIONS The modalities of evaluation range from basic pelvic examination, examination of the vulva, and laboratory tests. OUTCOMES A comprehensive approach to the detection of vaginal atrophy and a discussion of available therapeutic and nontherapeutic options. EVIDENCE...

BACKGROUND Aromatase inhibitors (AI) are increasingly used in early breast cancer and there is a growing interest in associated long-term side-effects of profound estrogen suppression. Urogenital side-effects due to atrophic vaginitis are often managed with vaginal estrogen preparations. These are generally perceived to result in minimal systemic absorption of estrogen. We followed serum estrad...