The conjugation of benzoic acid with glycine, resulting in the formation of hippuric acid, takes place in liver (1) and kidney (2). The urinary output of this conjugate after the administration of benzoate is used to measure this aspect of hepatic function (3). Theoretically, decreased hippuric acid formation may be due to hepatic and/or renal disease or to an inadequate supply of glycine. In t...

Background: Volatile organic compounds (VOCs), including carcinogens and toxic compounds, are produced in petrochemical industries. We undertook this study in order to study workers’ respiratory exposure to different VOC concentrations and compare the results with the urinary levels of its metabolites and study the correlation between them in petrochemical industries. Materials and Met...

1. The urinary excretion of orally administered [(14)C]benzoic acid in man and 20 other species of animal was examined. 2. At a dose of 50mg/kg, benzoic acid was excreted by the rodents (rat, mouse, guinea pig, golden hamster, steppe lemming and gerbil), the rabbit, the cat and the capuchin monkey almost entirely as hippuric acid (95-100% of 24h excretion). 3. In man at a dose of 1mg/kg and the...

background: benzene, toluene, ethylbenzene and xylene (btex) are the most important toxic volatile compounds in the air and could be easily absorbed through the respiratory tract. in recent years, the risk of exposure to btex compounds, especially benzene as a carcinogen, has been considered in petroleum depot stations. objective: to assess the occupational exposure of petroleum depot workers i...

Xylene is a commonly used toxic volatile organic solvent. Diagnosis of acute xylene poisoning is limited by the lack of a readily available analytic assay. Methylhippuric acid, a metabolite of xylene excreted in the urine, is used for biomonitoring occupational exposures to xylene. We report two cases of acute occupational poisoning from xylene inhalation suggested by determination of high urin...

BACKGROUND Glues are strong, liquid adhesive derived from animal tissues. It has been shown that glue sniffing is associated with demyelinating polyneuropathy. The low molecular weight agents which cause occupational lung disease have generally included the isocyanates exposure to which could result in asthma among workers. Toluene is also used widely in glue and adhesive industry and household...

Buchet, J. P., and Lauwerys, R. R. (1973). British Journal ofIndustrial Medicine, 30, 125-128. Measurement of urinary hippuric and m-methylhippuric acids by gas chromatography. A gas chromatographic method for the determination of hippuric and m-methylhippuric acids in urine is described. A known amount of heptadecanoic acid (internal standard) is added to the urine before its extraction with e...

Two experiments were conducted to examine the effect of benzoic acid in the diet of lactating sows on urinary pH and nutrient digestibility. In the first experiment, three levels of benzoic acid in the diet were tested (0.5, 1.0, and 2.0%), while in the second experiment only one dietary level of benzoic acid (0.5%) was used. In the second experiment, the urinary excretion of benzoic acid and h...

background: volatile organic compounds (vocs), including carcinogens and toxic compounds, are produced in petrochemical industries. we undertook this study in order to study workers’ respiratory exposure to different voc concentrations and compare the results with the urinary levels of its metabolites and study the correlation between them in petrochemical industries. materials and methods: exp...