BACKGROUND Uremic pruritus is a common complication in patients undergoing dialysis. The pathophysiological mechanisms of pruritus in patients with end-stage renal disease remain unknown. Neuropeptides, including substance P, are postulated to play an important role in the pathogenesis of pruritus. The aim of this study was to evaluate the role of substance P in uremic pruritus in patients on h...

Uremic pruritus is a common problem in patients with end-stage renal disease (ESRD), but the underlying mechanisms are not yet fully understood. We aimed to investigate the association between severity of uremic pruritus and cutaneous serine protease activity, as well as proteinase-activated receptor-2 (PAR-2) expression. Twelve ESRD patients with pruritus, 4 ESRD patients without pruritus, and...

Abstract Background Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as one possible explanations. High blood lead levels (BLLs) have been noted to be associated poor nutritional status hemodialysis patients. Our aim study relation between p...

References 1. Khan TM, Aziz A, Suleiman AK. Effectiveness of posthemodialysis administration of pregabalin (75 mg) in treatment resistance uremia pruritus. J Pharm Bioallied Sci 2016;8:74‐6. 2. Rayner H, Baharani J, Smith S, Suresh V, Dasgupta I. Uraemic pruritus: Relief of itching by gabapentin and pregabalin. Nephron Clin Pract 2012;122:75‐9. 3. Shavit L, Grenader T, Lifschitz M, Slotki I. Us...

1. Kittisupamongkol W. Not all that itches is uraemic pruritus. Nephrol Dial Transplant 2009; doi: 10.1093/ndt/gfp239 2. Pauli-Magnus C, Mikus G, Alscher DM et al. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebocontrolled crossover study. J Am Soc Nephrol 2000; 11: 514–519 3. Neilly J, Martin A, Simpson N et al. Pruritus in diabetes mellitus: investig...

Pruritus is a common and bothersome problem among uremic patients which negatively affects life quality and prognosis of the patient. Various factors are known to be involved in the development of pruritus. The aim of this study was to assess the frequency and the factors which may have relationship with uremic pruritus, especially bone mineral metabolism indicators. Current cross-sectional stu...

BACKGROUND Uremic pruritus is a common and bothersome complaint among end-stage renal disease which affect between 25% and 60% of this population .But there is no decisive cure for treatment of it. In this study, the effects of omega-3 for treatment of pruritus were investigated in hemodialysis patients. METHODS A double-blind randomized study was carried out in the form of placebo-controlled...

conclusions in this study, topical application of sweet almond oil, which was not followed by any specific complications, was able to significantly reduce the uremic pruritus in hemodialysis patients; however, these findings require further studies. methods this study is a randomized clinical trial research. the study population consisted of patients referred in 2013 to the hd ward of shahid be...