The growing number of patients suffering from chronic renal disease is a challenge for the development of innovative therapies. Benefits of cell therapy in acute renal diseases in animal models have been reported but seldom for chronic lesions. We present evidence for the improvement of renal morphology in a model of tubulointerstitial fibrosis. Wistar rats were submitted to unilateral ureteral...

RATIONALE In patients with bilateral ureteral obstruction, the serum creatinine levels are often elevated, sometimes causing postrenal acute kidney injury (AKI). In contrast, those with unilateral ureteral obstruction present normal serum creatinine levels, as long as their contralateral kidneys are preserved intact. However, the unilateral obstruction of the ureter could affect the renal funct...

Abstract Background and Aims Renal fibrosis is the common pathway of various chronic kidney diseases progressing to end stage renal failure. Polycystin-1 (encoded by PKD1 gene) polycystin-2 PKD2 form a transmembrane complex function as stress sensor, which located in primary cilia. Polycystins are involved disease condition different organs. Mutation PKD genes causes autosomal dominant polycyst...

there are often duplicated ureter with types of congenital anomalies and associated clinical complications. the unilateral duplicated ureter was observed as an incidence result in usual dissection. during routine dissection of the body of an adult male with middle-aged 40-50 year old, the duality of unilateral incompletely ureter was seen in above. two branches of ureter are coalesce in 7 cm di...

six patients with mitral stenosis complicated by renal artery embolism studied prospectively are presented. in five patients there was unilateral and in one patient bilateral renal artery involvement. the diagnosis was confirmed by intravenous pyelography, retrograde pyelography, renal angiography, renal scan or a combination of these. all had atrial fibrillation, proteinuria and elevated ldh l...

Objective. To create a ureteral obstruction experimental model that can be proved through (99m)Tc-DTPA renal scintigraphy and histopathological studies, without causing total renal function loss. Materials and Methods. Ten New Zealand white rabbits were submitted to a surgical experiment to create a model of unilateral obstruction to urinary flow. Surgery procedure provided unilateral ureteral ...

Renal fibrosis is a crucial pathological phenomenon of chronic kidney disease (CKD) that contributes to the progressive loss renal function. Monocarboxylate transporter 1 (MCT1) plays an important role in clear cell carcinoma; however, MCT1 inhibitor alpha-cyano-4-hydroxycinnamic acid (α-CHCA) remains unclear. In this study, we evaluated α-CHCA, inhibitor, treating associated with CKD. We used ...

Fibrosis is the end point of most renal diseases, and several glycosaminoglycans have been shown to attenuate this process. Marine invertebrate glycosaminoglycans with unique structures have opened the possibility to test these new compounds on renal fibrosis. The effect of a fucosylated chondroitin sulfate from an echinoderm marine species is reported with the use of a model of renal fibrosis ...