We present a follow up contribution to further complement a previous commentary on the activity cliff concept and recent advances in activity cliff research. Activity cliffs have originally been defined as pairs of structurally similar compounds that display a large difference in potency against a given target. For medicinal chemistry, activity cliffs are of high interest because structure-acti...

The retreat of chalk cliffs fringing the eastern English Channel contributes shingle to the beaches which helps to protect the cliffs and slow down erosion. Conversely, cliff retreat endangers settlements and infrastructure on the clifftop. Rates of retreat have been calculated by a variety of methods over the past century, but no attempt has been made to provide a complete coverage that allows...

Abstract: The retreat of chalk cliffs fringing the eastern English Channel contributes shingle to the beaches which helps to protect the cliffs and slow down erosion. Conversely, cliff retreat endangers settlements and infrastructure on the clifftop. Rates of retreat have been calculated by a variety of methods over the past century, but no attempt has been made to provide a complete coverage t...

Purpose: This paper studies the regions of parameter space of engineering design in which performance is sensitive to design parameters. Some of these parameters (for example, the dimensions and compositions of components) constitute the design, but others are intrinsic properties of materials or Nature. The paper is concerned with narrow regions of parameter space, “cliffs”, in which performan...

An inspection of signal processing approach in order to estimate underwater network cardinalities is conducted in this research. A matter of key prominence for underwater network is its cardinality estimation as the number of active cardinalities varies several times due to numerous natural and artificial reasons due to harsh underwater circumstances. So, a proper estimation technique is mandat...

The role of activity cliffs in drug discovery projects is certainly two-edged: on the one hand, they often lead to the failure of QSAR modeling techniques; on the other, they are highly valuable for identifying key aspects of SARs. In the presence of activity cliffs the results of purely ligand-based QSAR approaches often remain puzzling, and the resulting models have limited predictive power. ...

Underwater robotics is currently a growing field. To be able to autonomously find and collect objects on the land and in the air is a complicated problem, which is only compounded within the underwater setting. Different techniques have been developed over the years to attempt to solve this problem, many of which involve the use of expensive sensors. This paper explores a method to find the dep...