نتایج جستجو برای: tumorigenicity
تعداد نتایج: 4632 فیلتر نتایج به سال:
Quantum dots (QDs) have shown great development potential in noninvasive imaging and monitoring of cancer cells in vivo because of their unique optical properties. However, the key issue of whether or not QDs-labeled cancer cells affect the proliferation, apoptosis and in vivo tumorigenicity ability has not been reported. The primary issue is if the results obtained from the noninvasive visuali...
Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon rege...
Activating mutations of RAS frequently occur in subsets of human cancers, indicating that RAS activation is important for tumorigenesis. However, a large proportion of these cancers still retain wild-type RAS alleles, suggesting that either the RAS pathway is activated in a distinct manner or another pathway is deregulated. To uncover novel tumor-suppressor genes, we screened an RNA-interferenc...
Whether epithelial-mesenchymal transition (EMT) is always linked to increased tumorigenicity is controversial. Through microRNA (miRNA) expression profiling of mammary epithelial cells overexpressing Twist, Snail or ZEB1, we identified miR-100 as a novel EMT inducer. Surprisingly, miR-100 inhibits the tumorigenicity, motility and invasiveness of mammary tumor cells, and is commonly downregulate...
By continuous in vitro passage in lipid-depleted media of a Kirsten sarcoma virus-transformed murine cell line (FK3T3), a new cell line has been established (AK3T3) which exhibits many of the in vitro growth characteristics of the untransformed parent cell line, BALB/3T3, A31 strain. The tumorigenicity of the AK3T3 cell line was compared with FK3T3 cells in mice fed diets varying in levels of p...
Proliferation, a key feature of cancer cells, accounts for the majority of cancer-related diseases resulting in mortality. MicroRNAs (miRNAs) plays important post-transcriptional modulation roles by acting on multiple signaling pathways, but the underlying mechanism in proliferation and tumorigenicity is unclear. Here, we identified the role of miR-150 in proliferation and tumorigenicity in leu...
Malignant mesothelioma is associated with asbestos exposure and remains resistant to all therapeutic intervention. Previous studies have suggested an enhancing role for platelet-derived growth factor (PDGF) in mesothelial tumorigenicity, although the mechanism by which PDGF facilitates tumorigenicity is unknown. Here, we evaluate the contribution of PDGF-A expression to mesothelial tumorigenici...
A new carcinogen, W-nitrosohexamethyleneimine (W-nitrosoperhydroazepine), was synthesized and given to rats of both sexes. The incidence of mixed malignant liver cell carcinomas and endothelial sarcomas was virtually 100% when the drug was given at 200 mg/liter for 8 weeks, while benign and malig nant epitheliomas of the tongue or esophagus occurred in about 30%. When the drug concentration was...
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