Chagas disease is a zoonosis transmitted by Trypanosoma Cruzi, which has become public health problem worldwide. The infection can be acute, chronic phases and reactivations, characterized heart involvement. We report the case of 33-year-old woman with stabbing chest pain, as well hemiparesis in left arm managed for 8 weeks, persistent electrocardiogram (ECG) showing rate 40 bpm. She referred t...

The aim of this study was to reevaluate the ecology of an area in the Atlantic Forest, southeast Brazil, where Chagas disease (CD) has been found to occur. In a previous study, immediately after the occurrence of a CD case, we did not observe any sylvatic small mammals or dogs with Trypanosoma cruzi cruzi infections, but Triatoma vitticeps presented high T. c. cruzi infection rates. In this stu...

The polymerase chain reaction showed high sensitivity for detecting Trypanosoma cruzi in the blood of mice, independent of clonal genotype (19, 20-T. cruzi I; 32, 39-T. cruzi II) or phase of the infection (acute or chronic).

Trypanosoma cruzi: Morphological and Microtubular Changes Related to Epimastigote Differentiation under Hyperosmotic Stress Alba Marina Gimenez1* and Estela E. Machado1 1Department of Molecular Biology, Faculty of Exact Sciences, Physical-Chemical and Natural Sciences, National University of Río Cuarto, Río Cuarto (X5800) Córdoba, Argentina SOJ Microbiology & Infectious Diseases Open Access Res...

La infección por Trypanosoma cruzi, agente etiológico de la enfermedad Chagas, es una zoonosis compleja. En el ciclo biológico T. cruzi intervienen mamíferos como hombre y animales domésticos (ciclo doméstico peridoméstico) o silvestres roedores carnívoros selvático). Desde punto vista epidemiológico perro reservorio más importante. El objetivo fue diagnosticar en caninos residentes del Valle A...

Trypanosoma cruzi affects millions of people worldwide. Clinical variability of Chagas disease can be due to the genetic variability of this parasite, requiring further genome studies. Here we report the genome sequence of the T. cruzi Dm28c clone (TcI), a strain related to the sylvatic cycle of the parasite.

Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant structural heterogeneity and bioactivities. In this work, it was synthesized a series of furanaphthoquinones through tandem reaction between lawsone (8) cyclic ketones the presence morpholine. This strategy provides an efficient general method synthesizing with activity against epimastigote form Trypanosoma cruzi ...

INTRODUCTION For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological characterization, and the paucity of information on the clinical and biological aspects of Chagas disease in Mexico, this study aimed to identify the mo...

El objetivo de este estudio fue utilizar la reacción en cadena polimerasa (PCR) para detectar ADNk Trypanosoma cruzi tejidos cardíacos embebidos parafina 18 perros con miocarditis muerte súbita y/o signos sugestivos tripanosomiasis. La PCR resultó positiva 7 nidos amastigotos T. y 11 sin evidencia parásitos. Se describen los hallazgos clínicos patológicos estos caninos.

Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the ...