BACKGROUND Altered sialylation has been observed during oncogenic transformation. Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumor progression and metastases. In the cervical cancer high levels of sialic acid have been reported in the patients serum, and an increased of total sialic acid concentration has been reported for the cervical neoplasia and cer...

BACKGROUND: The prevalence of diabetes is steadily increasing worldwide particularly in developing countries, it is associated with chronic complications which lead to considerable mortality and morbidity. Type II diabetes is considered as a disease of innate immune response, sialic acid represent as a marker of acute phase protein is found to be elevated in diabetic subjects. MATERIALS AND MET...

BACKGROUND We investigated the relationship between serum levels of total sialic acid, lipid bound sialic acid and acute pancreatitis in a rat model of a common bile duct ligation induced acute pancreatitis. METHODS Twenty five Sprague-Dawley male rats weighing 250-300 g were divided into two groups (n=10: control, n=15: experimental). In the control group only a sham laparotomy was performed...

Sialic acid of seminal fluid of eighty two human subjects has been studied in relation to infertility. Normozoospermic group had highest sialic acid content (94 mgm/100 mt of the fluid) and was sign ificantly different from other groups. The lowest sialic acid level was observed: n necrozoosperm ic group (54 mgm/1 00 mt of the fluid). Azoospermic (62 mgm/100 ml) and vasectomised group (73 mgm/1...

Low density lipoprotein (LDL) with low sialic acid content has been reported to cause intracellular cholesterol accumulation, and therefore desialylation has been proposed to be an atherogenic modification of LDL. However, it is not known whether hypolipidemic treatment has any effect on LDL sialylation. Accordingly, we investigated the sialic acid/apolipoprotein (apo) B ratio of total LDL and ...

From 61 to 92% of the total sialic acid of a variety of human lymphoid cell lines maintained in tissue culture is present on the cell surface as measured by its susceptibility to cleavage by Clostridium perfringens neuraminidase. These cells contain from 1.22 x 10(8) to 6.99 x 10(8) molecules of surface sialic acid per cell. In synchronized cultures synthesis of surface sialic acid occurs only ...

Introduction: Oral squamous cell carcinoma is the most common malignant neoplasm in the head and neck region and remains one of the major causes of worldwide deaths. Recognition and diagnosis of oral cancer at an early stage can reduce morbidity and mortality. Oral cancer screening in a large population can be done non-invasively by using sialic acid in saliva as a biological marker. The aim of...

The present study was done to assess the levels of total sialic acid & lipid associated sialicAcid. Lactate dehydrogenase and total proteins in sera of patients with various malignant diseases and compared with sera of non malignant diseases, benign tumors & controls. Serum total sialic acid, LASA & LDH values are significantly increased in malignancies when compared to the controls (P<0.001), ...

1. The total sialic acid content of human gastric aspirates was measured using a colorimetric assay. Care was taken to optimize the assay and to eliminate interference. 2. The sialic acid content of gastric aspirates collected under resting conditions from 77 patients with non-ulcer dyspepsia was found to decrease with age from > 100 micrograms/ml at 25 years and younger to < 20 micrograms/ml a...

hereditary inclusion body myopathy (hibm) is an adult-onset hereditary myopathy, usually with distal onset and quadriceps sparing. this myopathy is autosomal recessive and associated to upd-n-acetylglucosamine-2-epimerase/n-acetylmannosamine kinase (gne) gene mutations. in this study, we report a novel gne homozygous point mutation c.1834t>g that results in amino acid substitution of cysteine 6...