H2O2-driven enzymes are of great interest for industrial biotransformations. Herein, we show the first time that oxalate oxidase (OXO) is an efficient in situ source H2O2 one these biocatalysts, which known as unspecific peroxygenase (UPO). OXO reasonably robust, produces only CO2 a by-product and uses cheap sacrificial electron donor. UPO has significant potential catalyst selective C−H oxyfun...