نتایج جستجو برای: tnbc

تعداد نتایج: 1923  

2014
Sara Jansson Pär-Ola Bendahl Dorthe Aamand Grabau Anna-Karin Falck Mårten Fernö Kristina Aaltonen Lisa Rydén

BACKGROUND Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-...

2017
Janet Yeh Jennifer Chun Shira Schwartz Annie Wang Elizabeth Kern Amber A Guth Deborah Axelrod Richard Shapiro Freya Schnabel

PURPOSE The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. METHODS Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. RESULTS Out...

2016
Mingming Lv Pengfei Xu Ying Wu Lei Huang Wenqu Li Shanshan Lv Xiaowei Wu Xin Zeng Rong Shen Xuemei Jia Yongmei Yin Yun Gu Hongyan Yuan Hui Xie Ziyi Fu

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer with high heterogeneity. To date, there is no efficient therapy for TNBC patients and the prognosis is poor. It is urgent to find new biomarkers for the diagnosis of TNBC or efficient therapy targets. As an area of focus in the post-genome period, long non-coding RNAs (lncRNAs) have been found to play critical roles in ...

Journal: :basic and clinical cancer research 0
sanaz rismanchi cancer biology research center, cancer institute, tehran university of medical sciences, tehran, iran ahad muhammadnejad cancer research center, cancer institute, tehran university of medical sciences, tehran, iran elahe keyhani genetics research center, university of social welfare & rehabilitation sciences, tehran, iran samad muhammadnejad research center for molecular and cellular imaging, tehran university of medical sciences, tehran, iran saeid amanpour cancer biology research center, cancer institute, tehran university of medical sciences, tehran, iran

background: for xenograft models of triple-negative breast cancer (tnbc) to be valuable in development of molecularly-targeted drugs, careful characterization is essential to their validation. the present study aimed to validate the tnbc xenograft model with a specific focus on angiogenesis. methods : twelve tnbc xenograft tumors and 12 human breast cancer tumors (htnbc) were included in this s...

Journal: :Clinical chemistry 2014
Hong Xu Peter Eirew Sarah C Mullaly Samuel Aparicio

BACKGROUND Triple-negative breast cancers (TNBC) do not represent a single disease subgroup and are often aggressive breast cancers with poor prognoses. Unlike estrogen/progesterone receptor and HER2 (human epidermal growth factor receptor 2) breast cancers, which are responsive to targeted treatments, there is no effective targeted therapy for TNBC, although approximately 50% of patients respo...

2017
Chun-Yu Liu Ka-Yi Lau Chia-Chi Hsu Ji-Lin Chen Chia-Han Lee Tzu-Ting Huang Yi-Ting Chen Chun-Teng Huang Po-Han Lin Ling-Ming Tseng

OBJECTIVES Triple negative breast cancer (TNBC) lacks specific drug targets and remains challenging. Palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor is approved for metastatic estrogen receptor (ER)-positive and human epithermal growth factor 2 (HER2)-negative breast cancer. The nature of cell cycle inhibition by palbociclib suggests its potential in TNBC cells. Retinoblastom...

2017
Li Min Cheng Zhang Like Qu Jialiang Huang Lan Jiang Jiafei Liu Luca Pinello Guo-Cheng Yuan Chengchao Shou

BACKGROUND Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Genome-scale molecular characteristics and regulatory mechanisms that distinguish TNBC from other subtypes remain incompletely characterized. RESULTS By combining gene expression analysis and PANDA network, we defined three different TF regulatory patterns. A core TNBC-Specific TF Activation Driven Pattern...

2015
Tao Han Zhaozhe Liu Hengyu Li Wanqing Xie Ranran Zhang Li Zhu Fang Guo Yaling Han Yuan Sheng Xiaodong Xie

BACKGROUND Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that is prone to recurrence and metastasis with worse prognosis. Epirubicin-based chemotherapy is of great importance for patients with TNBC, but resistance to epirubicin severely limits the application of this drug and this has emerged as a major problem in the treatment of TNBC. The ubiquitin protein D...

2016
Magdalena L. Plasilova Brandon Hayse Brigid K. Killelea Nina R. Horowitz Anees B. Chagpar Donald R. Lannin

The aim of this study was to determine the features of triple-negative breast cancer (TNBC) using a large national database. TNBC is known to be an aggressive subtype, but national epidemiologic data are sparse. All patients with invasive breast cancer and known molecular subtype diagnosed in 2010 to 2011 were identified from the National Cancer Data Base (NCDB). Patients with and without TNBC ...

2017
Yu-Cheng Su Pierre-Alain Burnouf Kuo-Hsiang Chuang Bing-Mae Chen Tian-Lu Cheng Steve R. Roffler

Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal growth factor receptor (EGFR) has emerged as a promising target for TNBC therapy because it is overexpressed in about 50% of TNBC patients. Here we describe a PEG engager that simultaneously binds polyethylene glycol and EGFR to deliver PEGylated nanomedici...

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