Lung cancer is the leading cause of cancer-related death worldwide. Recent progress in lung cancer diagnosis and treatment has been achieved due to a better understanding the molecular mechanisms of the disease and the identification of biomarkers that allow more specific cancer treatments. One of the best known examples of personalized therapy is the use of tyrosine kinase inhibitors, such as ...

OBJECTIVE Few data exist measuring the effect of differentiating drug-drug interaction (DDI) alerts in computerized provider order entry systems (CPOE) by level of severity ("tiering"). We sought to determine if rates of provider compliance with DDI alerts in the inpatient setting differed when a tiered presentation was implemented. DESIGN We performed a retrospective analysis of alert log da...

BACKGROUND Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter-observer and sampling-dependent variation in the histologic staging of dysplasia make clinical risk assessment problematic. In this stu...

In CMU's Blizzard Challenge 2005 entry we investigated twelve ideas for improving Festival-based unit selection voices. We tracked progress by adopting a 3-tiered strategy in which candidate ideas must pass through three stages of listening tests to warrant inclusion in the final build. This allowed us to evaluate ideas consistently without us having large human resources at our disposal, and t...

Research on communication collection pattern for traditional fixed nodes with some mobile ones has been already extensive. However, almost nothing is done in tiered movement policy while movement track is unknown and sensor nodes drift at random direction. To fit the development of “smart dust” wireless sensor network, a new moving control strategy based on RSSI real-time localization is propos...