An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations ...

Recent studies demonstrate an increased teratogenic risk for valproate and a probable increased risk for phenobarbital. Carbamazepine and lamotrigine appear relatively safe; however, results are inconclusive concerning a specific risk for cleft lip/palate for both drugs as well as a dose-dependent effect for malformations associated with lamotrigine. Data regarding teratogenic risks for other a...

The chapter summarizes literature on the teratogenic effects of anticonvulsants and presents data from the Swedish Medical Birth Register. Many anticonvulsants have a teratogenic effect which varies between individual drugs with the highest risk associated with the use of valproic acid and probably topiramide. For some much used drugs like carbamazepine and lamotrigine the risk is not much elev...

Methomyl is an oxime carbamate pesticide that is widely used in the Philippines. This insecticide is known to be an endocrine disrupting chemical and a potent genotoxic in mammalian cells. However, limited studies were conducted specifically on its direct effects on estrous cycle and its teratogenic effect. This study aimed to (a) assess the effect of methomyl on the body weight and on the estr...

Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...

Methomyl is an oxime carbamate pesticide that is widely used in the Philippines. This insecticide is known to be an endocrine disrupting chemical and a potent genotoxic in mammalian cells. However, limited studies were conducted specifically on its direct effects on estrous cycle and its teratogenic effect. This study aimed to (a) assess the effect of methomyl on the body weight and on the estr...

Pregnant Wistar rats were each injected once ip with various doses of 2-amino-l,3,4-thiadiazole hydrochloride (ATDA) at days 1-16 of gestation (sperm day = day 0). The optimal teratogenic dose was determined to be 100 mg/kg and this dose was employed throughout the experiment, At autopsy at day 20 resorptions and malformations were found in all litters from treated females. Two periods of incre...

Environmental teratogenic factors (e.g. alcohol) are preventable. We focus our analysis on human teratogenic drugs which are not used frequently during pregnancy. The previous human teratogenic studies had serious methodological problems, e.g. the first trimester concept is outdated because environmental teratogens cannot induce congenital abnormalities in the first month of gestation. In addit...