نتایج جستجو برای: tdm

تعداد نتایج: 1779  

Journal: :Annals of clinical and laboratory science 1997
S S Syed R L Hunter

Quartz and trehalose 6,6'-dimycolate (TDM) both potentiate tuberculosis and have toxicities that depend on surface crystalline structures. Investigations were undertaken to determine if TDM can kill macrophages and produce hemolysis in a fashion similar to that of quartz and if quartz can induce granulomas similar to those induced by TDM. Trehalose 6,6'-dimycolate was spread as a molecular mono...

2017
Emmanuel C. Patin Anna C. Geffken Sam Willcocks Christoph Leschczyk Albert Haas Falk Nimmerjahn Roland Lang Theresa H. Ward Ulrich E. Schaible

The causative agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), contains an abundant cell wall glycolipid and a crucial virulence factor, trehalose-6,6'-dimycolate (TDM). TDM causes delay of phagosome maturation and thus promotes survival of mycobacteria inside host macrophages by a not fully understood mechanism. TDM signals through the Monocyte-INducible C-type LEctin (Minc...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2003
John G Gerber Edward P Acosta

The use of therapeutic drug monitoring (TDM) in the treatment of HIV-infection is gaining momentum in resource-rich countries. However, data justifying its use is still in short supply. In this manuscript we review the necessary components of TDM before it should be implemented in widespread clinical use. In addition, we provide specific examples of clinical situations where TDM is likely to us...

Journal: :Infection and immunity 1981
F Kierszenbaum D R Walz

Cord factor--a mixture of 6,6'-diesters of alpha, alpha-D-trehalose with natural mycolic acids--which is purified from mycobacteria and other microorganisms, is known to have adjuvant activity as well as to enhance nonspecific resistance to infections and tumor development. In this work, trehalose 6,6'-dimycolate (TDM) was found to induce proliferative responses in rat thymus and lymph node cel...

2009
Eri Ishikawa Tetsuaki Ishikawa Yasu S. Morita Kenji Toyonaga Hisakata Yamada Osamu Takeuchi Taroh Kinoshita Shizuo Akira Yasunobu Yoshikai Sho Yamasaki

Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which contains various unique components that affect the host immune system. Trehalose-6,6'-dimycolate (TDM; also called cord factor) is a mycobacterial cell wall glycolipid that is the most studied immunostimulatory component of M. tuberculosis. Despite five decades of research on TDM, its host receptor has not been cle...

Journal: :Journal of Korean Society for Clinical Pharmacology and Therapeutics 1995

2005
Pierre Baumann Sven Ulrich Gabriel Eckermann Manfred Gerlach Hans-Joachim Kuss Gerd Laux Bruno Müller-Oerlinghausen Marie Luise Rao Peter Riederer Gerald Zernig Christoph Hiemke

Therapeutic drug monitoring (TDM) of psychotropic drugs such as antidepressants has been widely introduced for optimization of pharmacotherapy in psychiatric patients. The interdisciplinary TDM group of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) has worked out consensus guidelines with the aim of providing psychiatrists and TDM laboratories with a tool t...

Journal: :Contact dermatitis 2014
Kristina Ryberg Tove Agner Klaus E Andersen Andreas Bircher Thomas Diepgen Caterina Foti Ana Giménez-Arnau Margarida Gonçalo An Goossens Jeanne D Johansen Christophe Le Coz Howard I Maibach Magnus Bruze

BACKGROUND Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series. OBJECTIVES To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries. PATIENTS/MATERIALS/METHODS Two thousand nine hundred and seven conse...

2014
Hanne Schoenen Alexandra Huber Nada Sonda Stephanie Zimmermann Jonathan Jantsch Bernd Lepenies Vincenzo Bronte Roland Lang

Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, and its synthetic analog Trehalose-6,6-dibehenate (TDB) bind to the C-type lectin receptors macrophage-inducible C-type lectin (Mincle) and Mcl to activate macrophages. Genetically, the tran-scriptional response to TDB/TDM has been defined to require FcRg-Syk-Card9 signaling. However, TDB/TDM-triggered kinase activation has not been...

Journal: :The new microbiologica 2007
Alessia Uglietti Francesca Genco Elena Donadel Serena Rinaldi Erica Bastiani Renato Maserati Valeria Meroni

Therapeutic drug monitoring (TDM) is an important tool in the management of antiretroviral (ARV) therapy. The gold standard for measuring drugs plasma levels is High-Performance Liquid Chromatographic Assay (HPLC) however it is technically-demanding and time-consuming. We evaluated a new immunoenzymatic test (TDM-ELISA, Biostrands, Trieste, Italy) for nelfinavir and its active metabolite M8 in ...

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