A data warehouse was used to examine the LDL levels for patients who were switched from whole to half tablets of simvastatin. The LDL levels were available both pre and post conversion. 7,321 patients were switched and the LDL levels for these patients were tracked. 1,408 patients had a slight increase in LDL (less than 15% above baseline). Those patients whose LDL increased by greater than 15%...

Aim The angiotensin-converting enzyme inhibitor, enalapril, is considered a first-line treatment for chronic heart failure in children. However, there lack of an age-appropriate formulation and tablet splitting, although not recommended, common, attempt, to provide suitable doses paediatric use. An analysis currently available UK brands explored the accuracy splitting low-dose tablets enalapril...

UNLABELLED The aim of this study was to evaluate whether there exists any discrepancy between the European Pharmacopoeia (Ph. Eur.) and adopted United States Pharmacopeia (USP) tests concerning the weight uniformity measurements of tablet halves after splitting. The USP method does not contain provisions to evaluate split tablets, so here we adopt their whole tablet weight uniformity method. Tw...

Tablets are one of the most popular and preferred solid dosage forms because they can be accurately dosed, easily manufactured and packaged on a large scale, have good physical and chemical stability, and can contribute to good patient compliance given their ease of administration. The ability to match doses to patients depends on the availability of multiple dose sizes and adequate dose-respon...

The practice of tablet splitting as a way to reduce prescription medication costs has become increasingly prevalent. The United States Pharmacopeial Convention (USPC) has no standards for the subdivision characteristics of scored tablets. Literature results show that many tablets on the US market exhibit unacceptable subdivision characteristics. The European Pharmacopoeia (EP) provides requirem...