Summarv TeJ pigments, the oxidative products of tea polyphenols. mainly contain [eJ theJt1a\'ins. thearubigins and other components. In short-renn screening studies. tea pigments \vas found to have significant inhibitory efffects in Gene mutation test. Micronuclei fonnation test. rvletabolic cooperation test. \ilice ear edema test. Viability and growth ability of Hela cells in soft agar and S-1...

This review paper describes briefly on the history of aflatoxins, the metabolism of aflatoxin B1 (AFB1) that leads to the activation and detoxification of AFB1, and the findings of some of the studies relating to food nutrients and additives, and drugs on AFBJ carcinogenicity and detoxification. Aflatoxins have been linked to many public health problems, especially to liver cancer incidences, i...

Glutathione S-transferases (4) are involved in numerous plant physiological processes such as herbicide resistance (8), senescing flower petal response to ethylene (7), host response to pathogenic attack (2), and mammalian systems in the detoxification of xenobiotics. It has also been proposed that human glutathione S-transferase interacts with mercury, copper, and cadmium, therefore becoming a...

Magnetic Resonance Imaging instruments rely on a contrast agent to provide high-resolution images of tissues in vivo. However, current clinical contrast agents are hindered by low relaxivity and fast correlation time, necessitating high injection dosages. These concerns, among others, have driven the development of a class of protein-based contrast agents (ProCAs), by design of lanthanide bindi...

Aim of the study: Green tea catechin possesses antioxidant and free radical scavenging activity which stimulate detoxification system through selective induction or modification of phase I and phase II metabolic enzymes. This study was carried out to assess the antioxidative and antimetalotoxic effect of green tea Catechin against cadmium chloride in mice. Method: Adult Swiss albino mice were i...

immediate response of eukaryotic cells to oxidative. PARP-1 and PARP-2 display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. Recent studies suggest a link between DNA damage-induced poly(ADP-ribosyl)ation and all tissues at varying levels, with the highest activity in mammalian testis, spleen and thymus. in particula...

Allitinib, a novel irreversible selective inhibitor of the epidermal growth factor receptor (EGFR) 1 and human epidermal receptor 2 (ErbB2), is currently in clinical trials in China for the treatment of solid tumors. It is a structural analog of lapatinib but has an acrylamide side chain. Sixteen metabolites of allitinib were detected by ultra-high-performance liquid chromatography/quadrupole t...

Cytosolic carbonic anhydrase II (CAII) and the cytoplasmic C-terminal tails of chloride/bicarbonate anion exchange (AE) proteins associate to form a bicarbonate transport metabolon, which maximizes the bicarbonate transport rate. To determine whether cell surface-anchored carbonic anhydrase IV (CAIV) interacts with AE proteins to accelerate the bicarbonate transport rate, AE1-mediated bicarbona...

The electrophilic, free radical and reactive oxygen species scavenging and detoxification potentials of Lophiraalata stem bark was evaluated. L. alata stem bark effectively scavenged DPPH radical, superoxideion and hydrogen peroxide. It produced 88% scavenging effect of DPPH radical at a concentration of 1.0 mg/ml. Aqueous extract of L. alata-stem bark produced 76% and 92% scavenging effect on ...

In the present study, we aimed to design the intrauterine and extrauterine exposure to 1800 MHz GSM-like RF radiation and investigate its possible bio-effects on infant female rabbits. Totally thirty-six New Zealand White female rabbits, onemonth old, were randomly divided into four groups which are composed of 9 rabbits; i. Group I [Intrauterine (IU) exposure(-); Extrauterine (EU) exposure (-)...