Myotonic dystrophy is a multisystemic disorder characterized by repeat expansion mutations of the dystrophia myotonica protein kinase (DMPK) gene resulting in a defective muscular insulin receptor and insulin resistance. We describe a patient with myotonic dystrophy who developed biopsy-proven non-alcoholic steatohepatitis. We suggest that patients with myotonic dystrophy are at risk of develop...

introduction: silymarine extract is currently prescribed by some physicians for treatment of fatty liver disease. in the present study, the effect of administration of tablet containing silymarine extract on plasma homocysteine (hcy), folate, vitamin b12 and liver enzymes activity in non-alcoholic steatohepatitis (nash) was investigated. materials and methods: seventy-four patients (40 female a...

background nonalcoholic steatohepatitis (nash) is a common liver disease that can progress to cirrhosis or hepatocellular carcinoma. it is estimated that up to 3% of the iranian population have this condition. although the pathogenesis of nash is incompletely understood, there is significant evidence pointing to the importance of insulin resistance. metformin is an oral hypoglycemic agent known...

BACKGROUND There have been scant reports on the cumulative effects of atherosclerotic risk factors on steatohepatitis. METHODS We defined cases of steatohepatitis (n = 124) from one health examination center at National Taiwan University Hospital from January to December 2002. We selected controls, matched by age, gender and drinking status. Metabolic syndrome was defined by the modified ATP-...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. Its histopathology and the effects of nutrition on liver function have not been fully determined. AIM To elucidate the cellular mechanisms of NAFLD induced by a methionine-choline-deficient (MCD) diet in mice. Particular focus was placed on the rol...

conclusions elevated serum pth level was the predictive factor for nash in morbidly obese patients. also, we reported elevated serum liver enzymes, high serum pth levels and older age as predictors of nash in patients seeking obesity surgical treatments. results forty-six patients (34 women, aged 36.5 ± 10.6 years) were analyzed. the mean levels of liver enzymes were significantly higher in the...

non-alcoholic steatohepatitis is a form of chronic hepatitis. fatty degeneration may involve liver focally or as a whole. the patient was a 41-year-old woman who was diabetic and admitted in buali hospital in ghazvin because of right flank pain, fever, vomiting and diarrhea. the patient was treated as pyelonephriris. liver function tests were as below: alt: 62 (40) ast: 54 (40), alkaline phosoh...

Excess alcohol consumption and the associated development of alcoholic liver disease (ALD) are major public health challenges worldwide. Since patients with the severe stages of ALD no longer benefit from clinical therapies, early warning of ALD holds significant promise for increasing the cure rate of ALD. Herein, we develop a bicolor fluorescent nanoprobe for dynamically monitoring the conver...

We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a) and Cyp2e1 are potential hepatic sources of ROS. We tested the hypothesis that increasing Cyp4a through activation of peroxisome proliferator-activated receptor alpha (PPARalpha) should aggravate steatohepatitis prod...

OBJECTIVE The majority of cases of hepatocellular carcinoma have been reported in individuals with cirrhosis due to chronic viral hepatitis and alcoholism, but recently, the prevalence has become increasingly related to nonalcoholic steatohepatitis around the world. The study aimed to evaluate the clinical and histophatological characteristics of hepatocellular carcinoma in Brazilians' patients...