INTRODUCTION Statins reduce coronary events in patients with coronary artery disease. MATERIAL AND METHODS Chart reviews were performed in 305 patients (217 men and 88 women, mean age 74 years) not treated with statins during the first year of being seen in an outpatient cardiology practice but subsequently treated with statins. Based on the starting date of statins use, the long-term outcome...

Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies shown efficacy statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses. The ability inhibit viruses, as well Ebola, Zika, Dengue, Coxsackie, rotaviruses, ADV, HDV, HHV was experimentally confirmed. Statins can also enhance the effects drugs, mak...

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease, and its treatment still controversial. Statins have been proven to anti-inflammatory immunomodulatory effects, but their effectiveness in the of COPD unclear. We conducted this meta-analysis more accurately evaluate therapeutic effect statins on patients.

Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small GTPases. Statins are thus considered as potential therapeutic drug for the inflammatory demyelinating disease multiple sclerosis (MS). However, little is known about the effects of statins on myelin-form...

background and aims. statins, the mevalonate pathway inhibitors, have effects on bone formation in vitro and in vivo. the aim of the present study was to investigate whether injection of statins could lead to ectopic bone formation in rats. materials and methods. a single dose (0.5 mg) of simvastatin, atrovastatin, lovastatin and polyethylene glycol (control material) were injected into four qu...

Antitumor drug treatment of hemoblastoses always takes into account the patient comorbidity. Due to frequent cardiovascular pathology and atherosclerosis, patients have take statins along with antitumor treatment. Experimental studies shown that inhibit cholesterol synthesis (necessary for vital activity malignant cells), isoprenylation RAS RHO oncogenes, proliferation leukemic cells. In additi...

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1,...

BACKGROUND AND PURPOSE Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. METHODS We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score < or =2 at 12 weeks and modif...

Background and Purpose—Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. Methods—We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score 2 at 12 weeks and modified Rank...