Solid self-emulsifying drug delivery system (SSEDDS), which incorporates liquid SEDDS into a solid dosage form, has been recently introduced to improve the oral bioavail-ability of poorly water-soluble drugs. However, supersaturated drug generated by SSEDDS is thermodynamically unstable and tends to precipitate rapidly prior to absorption, resulting in compromised bioavailability. The aim of th...

Production of αamylase under solid state fermentation by Streptomyces erumpens MTCC 7317 was investigated using cassava fibrous residue, one of the major solid waste released during extraction of starch from cassava (Manihot esculenta Crantz). Response surface methodology (RSM) was used to evaluate the effect of the main variables, i.e., incubation period (60 h), moisture holding capacity (60%)...

The rapid-release mechanisms of standard extract from Ginkgo biloba leaf (EGb) in the polyethylene glycol (PEG) 6000 dispersions were investigated. The apparent equilibrium solubilities of the total flavone glycosides and the soluble solid materials of EGb increased linearly with the increasing concentrations of PEG 6000 solutions. In DSC curves, the peak, onset and endset temperatures of solid...

Returning crop residues into the soil as a source of organic matter are an important source of copper and can play an important role in the soil fertility. In addition to the role of the organic matter in increasing the concentration of micronutrients in soil solution, attention should be also paid to the role of the kind and the quantity of the root’s exudates released in response to the incor...

Returning crop residues into the soil as a source of organic matter are an important source of copper and can play an important role in the soil fertility. In addition to the role of the organic matter in increasing the concentration of micronutrients in soil solution, attention should be also paid to the role of the kind and the quantity of the root’s exudates released in response to the incor...

effect of different fruit position on postharvest quality of f1 hybrid redfleshed watermelon hi-u 16 was examined. in this study only one main vine was trained and maintained. the plants were allowed to set three fruits naturally at the first (8th - 11th nodes), second (13th - 16th nodes) and third (18th - 21th nodes) position. fruits were harvested at 35 days after anthesis. fruit weight, diam...

X-irradiated Escherichia coli B, a filament-forming strain, showed improved survival of X-rays after treatment with its own extract, either in liquid or on solid media. Extract-promoted recovery was not shown by a non-filamentforming strain E. coli B,-~. We failed to observe liquid holding recovery of X-irradiated bacteria in the absence of extract. Most experiments were performed in liquid med...

Amorphous solid dispersions are of great current interest because they can improve the delivery of poorly water-soluble compounds. It has been recently noted that the highly supersaturated solutions generated by dissolution of some ASDs can undergo a phase transition to a colloidal, disordered, drug-rich phase when the concentration exceeds the "amorphous solubility" of the drug. The purpose of...