limitations. In a longitudinal study of visceral leishmaniasis in Bangladesh, Bern et al. reported loss of LST sensitivity attributed to antigen-production issues, such as standardization and documentation of sensitivity, potency, and stability of leishmanin antigens (5). Also, prior treatment with immunosuppressive agents, which influence cell-mediated immunity, may decrease LST prognostic pot...

Lupoid leishmaniasis, a clinical form of cutaneous leishmaniasis, was described by Christopherson in 1923 [1]. It is a chronic condition that typically follows acute cutaneous leishmaniasis infection. In this clinical form, 1 to 2 years after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. The papules have a granulomatous, lupoid appearance and a...

Phlebotomus duboscqi is the principle vector of Leishmania major, the causative agent of cutaneous leishmaniasis (CL), in West Africa and is the suspected vector in Mali. Although found throughout the country the seasonality and infection prevalence of P. duboscqi has not been established in Mali. We conducted a three year study in two neighboring villages, Kemena and Sougoula, in Central Mali,...

Herein we report a 6-year-old Afghans patient referred to Department of Dermatology, St. AL-Zahra Hospital in Isfahan with ulcerative and nodular lesions disseminated over the face, arms, buttocks, pelvic girdle and legs in 2002. Direct smears of the lesions were positive for Leishman bodies. Leishmanin skin test was negative. He also had dactylitis in some digits and toes. PCR from bone biopsy...

BACKGROUND Traditional methods of detecting Leishmania from cutaneous lesions involve invasive diagnostic procedures, such as scrapings, which cause discomfort, require technical expertise, and carry risks of invasive procedures. We compared the performance of 2 novel, molecular-based non-invasive methods for the diagnosis of cutaneous leishmaniasis (CL). METHODS Consecutive patients presenti...

multiple sclerosis (ms) is an autoimmune disease of central nervous system. since different types of immune cells are involved in ms pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble cd4 (scd4), scd8, scd163, and immunoglobulins as markers of activity of t-cells, macrophages, and b-cells in different types of ms. serum levels of ...

Both urban and rural cutaneous leishmaniasis (CL) are endemic in different parts of Iran and have long been recognized in most provinces. However, there is no report of endemicity of CL in rural areas of Kashan, 200 km north of Isfahan and 260 km south of Tehran, Iran. To our knowledge, this is the first report of outbreak of cutaneous leishmaniasis in this area. To study and iden...

LTB 131, a 12 year old boy, came to the clinic with a typical leishmania ulcer on his right leg (20mm in diameter with a raised rolled edge) present for 6 months. Neither giemsa stained smears nor hamster inoculation showed evidence of parasites. Histology was compatible with the clinical diagnosis. The leishmanin test (using a 30ju,g dose of protein) was negative in 1980,1981, twice in 1983 (a...

This study was carried out in order to obtain base-line data concerning the epidemiology of American Visceral Leishmaniasis and Chagas' Disease in an indigenous population with whom the government is starting a dwelling improvement programme. Information was collected from 242 dwellings (1,440 people), by means of house to house interviews about socio-economic and environmental factors associat...