aluminum phosphide (alp) as 3 g tablet is widely used in iran to protect stored food grains from pests. hyperglycemia following its ingestion has been already reported in the recent years but severe hypoglycemia is uncommon. here, we report a 19 year old male who attempted suicide with one tablet of alp and demonstrated severe hypoglycemia. despite restoration of blood glucose concentration to ...

propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. in iran, several pharmaceutical manufacturers formulate these two b-blockers. as the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evaluate...

OBJECTIVES To assess the efficacy and safety of NSF-3, a polyherbal sedative-hypnotic (containing standardized extracts of Valeriana officinalis, Passiflora incarnate and Humulus lupulus), in comparison to zolpidem in primary insomnia. MATERIALS AND METHODS The present study was designed as a parallel group, double- blind, randomized, controlled trial and registered with Clinical Trials Regis...

BACKGROUND Older people with dementia may be particularly susceptible to cognitive impairment associated with anticholinergic and sedative medicines. This impairment may be misattributed to the disease process itself. OBJECTIVE This review examines clinical considerations associated with using anticholinergic and sedative medicines in people with dementia or incipient cognitive impairment. It...

In spite of tremendous advances in medical science, sleep has not been understood completely. The causes for many of parasomnias are still not evident. Even then these parasomnias are treated with different drugs, one of the major groups among them being sedative hypnotics. The use of sedative hypnotics are always associated with adverse effect, and there is many a times loss of the normal slee...

Introduction Patients under mechanical ventilation in the Intensive Care Unit (ICU) require sedation in order to facilitate ventilator and endotracheal tube tolerance. The sedative agent that must be used should not interfere with early extubation of patients. Midazolam is a benzodiazepine, a common sedative agent used in the ICU, while dexmetomidine is an alpha 2 adrenergic receptor agonist, t...