We studied the activation of 3',5'-cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) by using a cell-permeant enzyme inhibitor. Rods of Ambystoma tigrinum held in a suction electrode were jumped into a stream of 3-isobutyl-1-methylxanthine (IBMX), 0.01-1 mM. Initial transient light-sensitive currents fit the notion that dark and light-activated forms of PDE contributed independently...

The Finite Element Method (FEM) introduced by engineers in late 50's and 60's is a numerical technique for solving problems which are described by Ordinary Differential Equations (ODE) /Partial Differential Equations (PDE) with appropriate boundary/initial conditions or to solve problems that can be formulated as a functional minimization. FEM provides greater flexibility to model complex geome...

Parameterisation of facial expressions on PDE surface representations of human faces are presented in this work. Taking advantage of the boundary-value approach inherent to Bloor-Wilson PDE method, facial expressions are achieved by manipulating the original boundary curves. Such curves are responsible for generating a surface representation of a human face in its neutral configuration, so that...

In 32PO4-labeled adipocytes, isoproterenol (ISO) or physiologically relevant concentrations of insulin rapidly increased phosphorylation of a particulate 135-kDa protein which has been identified as a cGMP-inhibited "low Km" cAMP phosphodiesterase (CGI-PDE) by several criteria, including selective immunoprecipitation with anti-CGI-PDE IgG (Degerman, E., Smith, C.J., Tornqvist, H., Vasta, V., Be...

Analyses were done on a human type-IV cyclic AMP (cAMP) phosphodiesterase (hPDE-IVA-h6.1) expressed in an engineered strain of Saccharomyces cerevisiae. This strain (YMS6) expressed soluble PDE activity, together with an insoluble activity which was not released by re-homogenization, treatment with high-ionic-strength solutions or with the detergent Triton X-100. Pellet and soluble PDE activiti...

The paper deals with the local nonsolvability of several examples of linear and nonlinear partial differential equations. In the linear case we prove nonsolvability in Schwartz distribution space while in the nonlinear case we prove the nonexistence of classical solutions as well as the nonexistence of L∞ ∩ H s , s > 0, solutions. 1. This paper deals with the local nonsolvability of several exa...

In this article, we investigate the parabolic partial differential equations (PDEs) systems with Neumann boundary conditions via Takagi–Sugeno (T–S) fuzzy model. On basis of obtained T–S PDE model, a novel state controller which is associated position and mean value coefficient matrix derived through theorem integral designed to analyze asymptotic stability system. Without sampling nonlinear pa...

The trace element zinc affects several aspects of immune function, such as the release of proinflammatory cytokines from monocytes. We investigated the role of cyclic nucleotide signaling in zinc inhibition of LPS-induced TNF-alpha and IL-1beta release from primary human monocytes and the monocytic cell line Mono Mac1. Zinc reversibly inhibited enzyme activity of phosphodiesterase-1 (PDE-1), PD...

This paper considers the p-Laplacian PDE for p = 1,∞ and some interesting new game theoretic interpretations, due to Kohn–Serfaty [K-S] and to Peres–Schramm–Sheffield–Wilson [P-S-S-W].

s The PDE workshop on Analysis of Nonlinear PDEs and Free Boundary Problems: Applications to Homogenization