there are controversial reports regarding the role of peptidylarginine deiminase type 4 (padi4) gene polymorphisms and risk of rheumatoid arthritis (ra). the aim of the present study was to investigate the impact of padi4 rs1748033 polymorphism and susceptibility to ra in a sample of the iranian population.this case-control study was done on 150 patients with ra and 150 healthy subjects.padi4 r...

conclusions the detection of mycobacterium tuberculosis is always an important differential diagnosis for skin and soft tissue involvement in endemic areas. the cold abscess is an uncommon form of cutaneous tuberculosis that can be single or multiple and with or without fistula. case presentation the case was a 42-year-old female, a known case of rheumatoid arthritis that was receiving predniso...

rheumatoid arthritis and osteoporosis

high levels of rheumatoid factors (rf) are detectable in serum of the majority of patients with rheumatoid arthritis (ra), but 5-10% of patients remain seronegative (sn). despite clinical and genetic similarities between these two subsets of ra, it has been proposed that they may be regarded as distinct clinical entities. methods: in the present study a panel of monoclonal antibodies (mab) reco...

Objectives: Foot and ankle problems are common complications in rheumatoid arthritis disease. Gait pattern such as normal foot and ankle rocker is impaired in patients with rheumatoid arthritis. Rocker sole as an external shoe modification is commonly prescribed in this pathology. The aim of this study was to investigate the effect of rocker shoe on vertical ground reaction force parameters dur...

Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...

abstract background and objective: c- reactive protein (crp), as an acute phase reactant and a reliable marker of inflammation, increases due to inflammatory diseases such as rheumatoid arteritis and infectious conditions. new evidence shows that vitamin d may have important effects on adjusting and reducing the immune responses. the aim of this study was to evaluate the association between ser...

background increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (mtx). the aim of this study, therefore was to evaluate the incidence of mtx induced hepatotoxicity and its risk factors among rheumatoid arthritis (ra) patients. methods this retrospective study described 286 patients with ra who received ≤ 7.5 mg mtx weekly...