Data Grid provides sharing services for very large data around the world. Data replication is one of the most effective approaches to reduce access latency and response time. In addition to the benefits, replication has costs such as storage and bandwidth consumption, especially when storage space is low and limited. Therefore,  the data replacement should be done wisely. In this p...

in this paper by combining caching and replication techniques proposed a hybrid heuristic method based on the greedy algorithm to use the benefit of each other techniques. the algorithm in each interaction compares all the contents and one that made the best benefit value is selected for replication. the hybrid approach tested in a simulation environment and the results show that hybrid algorit...

The ds-RNA activated protein kinase (PKR) is a serine-threonine kinase with MW of 68 KDa. It belongs to a family of kinases that control one of the translational initiation factors, eIF2. PKR is produced at high level in response to viral infection. This protein by phosphorylating eIF2 inhibits cellular protein synthesis. In this study, the effect of gamma interferon (IFN-γ), an activator, and ...

Abstract— High-performance computing and vast storage are two key factors required for executing data-intensive applications. In comparison with traditional distributed systems like data grid, cloud computing provides these factors in a more affordable, scalable and elastic platform. Furthermore, accessing data files is critical for performing such applications. Sometimes accessing data becomes...

abstract - one of the important problems in grid environments is data replication in grid sites. reliability and availability of data replication in some cases is considered low. to separate sites with high reliability and high availability of sites with low availability and low reliability, clustering can be used. in this study, the data grid dynamically evaluate and predict the condition of t...

A complication in the analysis of the role of ICP34.5 gene in the herpes simplex virus type-1 (HSV-1) lifecycle is the presence of overlapping antisense gene, open reading frame P (ORF P), which is also deleted in HSV-1 ICP34.5 negative mutants. A HSV-1 wild type strain (17+) ICP34.5/ORF P deletion mutant (1716) is totally avirulent in animal models and impaired in a number of in vitro function...

Background and Aims: Oncolytic reoviruses can infect and kill malignant cells while sparing their normal counterparts. Reoviral infection can induce or activate autophagy, even though metformin can induce autophagy. Identifying and regulating the cellular pathways important for reovirus replication and oncolysis can improve targeted-biological therapies for cancer. Here, the autophagic process ...

Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed anti-influenza virus activity of pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus...

the varicella-zoster virus (vzv) genome contains both cis-acting and trans-acting elements, which are important in viral dna replication. the cis-acting elements consist of two copies of oris, and the trans-acting elements are those genes whose products are required for virus dna replication. it has been shown that each of the seven genes required for ori-dependent dna synthesis of herpes simpl...