Börjesson, Anna, Andreas Norlin, Xiangdong Wang, RolandAndersson, and Hans G. Folkesson. TNF-a stimulates alveolar liquid clearance during intestinal ischemiareperfusion in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L3–L12, 2000.—Intestinal ischemia-reperfusion commonly occurs in critically ill patients and may lead to the development of remote organ injury, frequently involving the lu...

SEE PAGE 47 A MP-activated protein kinase (AMPK) is a molecular energy sensor that is essential to the stress response in the heart (1). AMPK is activated during energy imbalance, when the ADPor AMP-toATP ratio increases. Because few proteins have adenine nucleotide binding domains, the activation of a protein kinase, which phosphorylates numerous downstream proteins, amplifies the energy stres...

Börjesson, Anna, Andreas Norlin, Xiangdong Wang, RolandAndersson, and Hans G. Folkesson. TNF-a stimulates alveolar liquid clearance during intestinal ischemiareperfusion in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L3–L12, 2000.—Intestinal ischemia-reperfusion commonly occurs in critically ill patients and may lead to the development of remote organ injury, frequently involving the lu...

Epidemiological studies show that particulate matter (PM) is the principal instigator of some adverse clinical symptoms involving cardiovascular diseases. PM exposure can increase experimental infarct size and potentiate myocardial ischemia and arrhythmias in experimental MI models such as ischemia-reperfusion (I/R) injury.The present study was aimed to evaluate the effects of particulate matte...

genesis of ischemia and reperfusion injury in the myocardium. Recent studies have suggested that a massive Ca influx may occur as a consequence of Na –Ca exchange via the sodium–calcium exchanger (NCX) during reperfusion which, in turn, may be caused by an accumulation of Na via the sodium–hydrogen exchanger (NHE) during ischemia. This results in an intracellular Ca overload, the detrimental ef...

The incidence and severity of primary cardiac events are inversely related to the plasma concentration of high-density lipoproteins (HDLs). We investigated whether HDLs may exert a direct cardioprotection in buffer-perfused isolated rat hearts, which underwent a 20-minute low-flow ischemia followed by a 30-minute reperfusion. The administration of HDLs at physiological concentrations (0.5 and 1...

The pathophysiology of multiple disease states, including sepsis,1,2 hypertension,1 atherosclerosis,3–5 and ischemiareperfusion injury,6 is characterized by loss of the endothelial barrier function leading to the accumulation of plasma-borne proteins, tissue edema, and cell death. Importantly therapeutic strategies that inhibit loss of endothelial barrier function have been associated with stra...