background: type 1 diabetes (t1d) is a t cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. autoimmune diseases may develop as a consequence of altered balance between regulatory (tregs) and autoreactive t cells. objectives: to evaluate treg cells frequency and suppressive function in the peripheral blood of newly diagnosed t1d patients in compari...

The global regulatory plan for vaccines provides a unique opportunity to develop safe and effective ones with assured quality. Methods used by regulators address challenges of new products and technologies and also increase understanding of benefits and risks of existing products. First, the laboratory-based regulatory sciences evolve correlates of immunity and safety; or improve the product ch...

The effect of motivational self-regulatory strategies on L2 learners’ achievement has scarcely been examined within the context of our country, Iran. This study is concerned with examining the relationship between motivational self-regulatory strategies and their L2 reading and L2 writing achievement. It also explores the relationship of motivational self-regulatory strategies and use of langua...

social entrepreneurship will create innovative solutions to solve critical social problems and mobilize the ideas, capacities, resources and social regulations needed for social changes. development of social entrepreneurship will undoubtedly play an important role in economic development, but because of social challenges that entrepreneurs have to cope with, it needs regulatory policies. revie...

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

background: it seems that the success of vaccination for cancer immunotherapy such as dendritic cell (dc) based cancer vaccine is hindered through a powerful network of immune system suppressive elements in which regulatory t cell is the common factor. foxp3 transcription factor is the most specific marker of regulatory t cells. in different studies, targeting an immune response against regulat...

The internet has transformed the manner of conducting commercial transactions and has created regulatory gaps. These regulatory gaps may impact the effective development of electronic commerce. Attempts are being made to regulate electronic contracts both at the national and international level. The present research analyses these attempts, in particular the Electronic Transaction Legislation ...

the sulfur regulatory circuit of the filamentous fungus, neurospora crassa, consists of a set of unlinked structural genes which encode sulfur catabolic and two major regulatory genes which govern their expression. the cys-3 regulatory gene encode a transacting regulatory protein which activates the expression of cys-14 and ars, whereas the other regulatory genes scon-l and scon-2 appear to act...

the biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. so far, many computational and statistical methods such as pca and ica have been employed for computing low-dimensional or hidden representat...