BACKGROUND Reproductive loss carries immeasurable human costs as well as being costly to the health care system. The objectives of this study were to determine the frequency and distribution of cytogenetically abnormal miscarriages from couples with recurrent miscarriage and to compare the results with the general population. METHODS A total of 420 specimens, including 29 pre-clinical, 237 em...

INTRODUCTION One percent of couples trying to have children are affected by recurrent miscarriage. These pregnancy losses have different pathogenetic (genetic, endocrine, anatomic, immunologic, microbiologic, haematologic and andrologic) backgrounds, but recurrent miscarriage remains unexplained in more than half of the affected couples. AIM To explore risk factors for recurrent pregnancy los...

STUDY QUESTION Is there any effect of maternal age on chromosomal anomaly rate and spectrum in recurrent miscarriage? SUMMARY ANSWER There was no significant difference in the chromosome abnormality rate between sporadic and recurrent miscarriage but the chromosome abnormality rate increased significantly with maternal age. WHAT IS KNOWN ALREADY About 50-70% of non-recurrent miscarriages oc...

BACKGROUND Histidine-rich glycoprotein (HRG) has previously been shown to have an impact on implantation and fertility. The aim of this study was to investigate if there is an association between the HRG A1042G single nucleotide polymorphism (SNP) and recurrent miscarriage. METHODS The study was designed as a case-control study and the women were included at University Hospitals in Sweden. 18...

Background and Aims: To date, several factors have been reported in recurrent miscarriage. Genetic mutations are the most important causative factors in women. Fetal thrombotic vasculopathy is a new described placental alteration with varying degrees of involvement and often associated with adverse prenatal outcomes. The diagnosis is made histologically and so is postnatal, which makes it a cha...

Blood pressure ≥ 140/90 (OR = 1.3), age ≥ 35 years (OR = 1.2), pure African race (OR = 1.3) and group A blood (OR = 1.3), have all appeared to slightly increase the risk of recurrent miscarriage. As the study was very small, a larger study is needed to either confirm or refute any possible causal relationship. Age < 35 years (OR = 0.89), Arabic race (OR = 0.7), history of contraceptive use (OR ...

Activated protein C (APC) resistance, both in its congenital form, due to the factor V Leiden mutation, and in its acquired form, are important risk factors for systemic venous thrombosis. In view of the suspected thrombotic aetiology of some cases of recurrent miscarriage, the prevalence of APC resistance was determined among 1111 consecutive Caucasian women with a history of either recurrent ...

OBJECTIVE To establish a method of estimating the proportion of women with a subsequent live birth after a well-defined time period in an open cohort of women referred to a tertiary recurrent miscarriage clinic. METHODS We performed a descriptive cohort study with register-based follow-up at a tertiary center for investigation and treatment of recurrent miscarriage in Denmark. All women with ...