Abstract R-loops are abundant and dynamic structures ubiquitously present in human cells both the nuclear mitochondrial genomes. They form cis wake of transcription complexes trans apart from complexes. In this review, we focus on relationship between topoisomerases, cancer genomics therapies. We summarize topological parameters associated with formation resolution R-loops, which absorb release...

A. Van de Ven has pointed out in connection with his recent results(1) that there are not many known examples of compact connected complex 4-manifolds with positive indices. The purpose of this note is to exhibit a series of compact connected complex 4-manfolds M . . . . n, m = 2, 3, 4, ..., with positive indices. Each complex 4-manifold Mn.m is an irregular algebraic surface having a structure...