BACKGROUND Pyometra often induces systemic inflammatory response syndrome (SIRS) and early diagnosis is crucial for survival. Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. A prognostic value of CgA has been found in humans that are critically ill or that have SIRS associated with infecti...

Spontaneous uterine rupture and generalized peritonitis caused by pyometra occurs rarely with high morbidity and mortality. A correct and definite diagnosis can be made with laparotomy or laparoscopy. The clinical findings of perforated pyometra are similar to perforation of the gastrointestinal tract and gynecologic symptoms are less frequent, which makes preoperative diagnosis difficult. We r...

This case describes a 71 year old, post-menopausal woman who developed vaginal discharge. This complaint ultimately led to the discovery of bowel cancer in conjunction with a large sterile pyometra.The pyometra was not due to genital malignancy. The most likely conclusion is that the pyometra may have arisen as an inflammatory response to the adjacent bowel pathology. This case report highlight...

Introduction Cystic endometrial hyperplasia-pyometra complex (CEH) is the most frequent and important endometrial disorder in bitches, the exact pathogenesis of which is still unknown (1). CEH is an abnormal response of the bitch's uterus to ovarian hormones (10) and is considered by many authors to be an exaggerated response of the uterus to chronic progestational stimulation during the luteal...

This study was designed to evaluate the role of E. coli α-hemolysin (HlyA) in the pathogenesis of canine pyometra, and on the immune response of canine endometrial epithelial and stromal cells. In Experiment 1, the clinical, hematological, biochemical and uterine histological characteristics of β-hemolytic and non-hemolytic E. coli pyometra bitches were compared. More (p < 0.05) metritis cases ...

Spontaneous perforation is a very rare complication of pyometra. The clinical findings of perforated pyometra are similar to perforation of the gastrointestinal tract and other causes of acute abdomen. In most cases, a correct and definite diagnosis can be made only by laparotomy. We report two cases of diffuse peritonitis caused by spontaneous perforated pyometra. The first case is a 78-year-o...

Pyometra is a life-threatening and hormone induced cystic endometrial hyperplasia seen predominantly in older bitches, complicated with secondary bacterial infections. This study was performed the objective of isolation antibiogram Escherichia coli from canine pyometra. Vaginal swabs were collected aseptically 20 pyometra cases, presented to Veterinary Clinical Complex, Puducherry (India) for i...

Pyometra is the accumulation of purulent material in the uterine cavity. Its reported incidence is 0.01-0.5% in gynecologic patients; however, as far as elderly patients are concerned, its incidence is 13.6% [3]. The most common cause of pyometra is malignant diseases of genital tract and the consequences of their treatment (radiotherapy). Other causes are benign tumors like leiomyoma, endometr...

INTRODUCTION By definition pyometra is a pus-filled uterus. Pyometra is typically a post-oestral syndrome in adult bitches associated with a variety of clinical and pathological manifestations of genital and multisystemic disease. Pyometra is most commonly associated with polydipsia, polyuria, abdominal distension, vomition, poor appetite, weight loss and anaemia. A purulent vaginal discharge m...

This report describes the clinical presentation, diagnosis and treatment of a queen with open pyometra. Lethargy, anorexia and previous treatment failure were the main reasons resulting in referral for diagnostic evaluation. The history, haematological and biochemical profiles and abdominal radiographs revealed open pyometra. Following ovariohysterectomy and antibiotic therapy there was total r...